Psoriasis and Other Complex Trait Dermatoses: From Loci to Functional Pathways

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80 Citations (Scopus)

Abstract

Driven by advances in molecular genetic technologies and statistical analysis methodologies, there have been huge strides taken in dissecting the complex genetic basis of many inflammatory dermatoses. One example is psoriasis, for which application of classical linkage analysis and genome-wide association investigation has identified genetic loci of major and minor effect. Although most loci independently have modest genetic effects, they identify important biological pathways potentially relevant to disease pathogenesis and therapeutic intervention. In the case of psoriasis, these appear to involve the epidermal barrier, NF-kappa B mechanisms, and T helper type 17 adaptive immune responses. The advent of next-generation sequencing methods will permit a more detailed and complete map of disease genetic architecture, a key step in developing personalized medicine strategies in the clinical management of the complex inflammatory dermatoses.
Original languageEnglish
Pages (from-to)915 - 922
Number of pages8
JournalJournal of Investigative Dermatology
Volume132
Issue number3
DOIs
Publication statusPublished - Mar 2012

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