Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease

N Wolf; M Quaranta; N J Prescott; M Allen; R Smith; A D Burden; J Worthington; C E M Griffiths; C G Mathew; J N Barker; F Capon; R C Trembath

doi:10.1136/jmg.2007.053595

Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease

N Wolf, M Quaranta, N J Prescott, M Allen, R Smith, A D Burden, J Worthington, C E M Griffiths, C G Mathew, J N Barker, F Capon, R C Trembath

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Abstract

Background: Psoriasis is an immune-mediated skin disorder that is inherited as a multifactorial trait. Linkage analyses have clearly mapped a primary disease susceptibility locus to the major histocompatibility complex (MHC) region on chromosome 6p21. More recently, whole-genome association studies have identified two non-MHC disease genes (IL12B and IL23R), both of which also confer susceptibility to Crohn disease (CD). Objective and methods: To ascertain the genetic overlap between these two inflammatory conditions further, we investigated 15 CD-associated loci in a psoriasis case-control dataset. Results: The analysis of 1256 patients and 2938 unrelated controls found significant associations for loci mapping to chromosomes 1q24 (rs12035082, p = 0.009), 6p22 (rs6908425, p = 0.00015) and 21q22 (rs2836754, p = 0.0003). Notably, the marker showing the strongest phenotypic effect (rs6908425) maps to CDKAL1, a gene also associated with type 2 diabetes. Conclusions: These results substantiate emerging evidence for a pleiotropic role for s genes that contribute to the pathogenesis of immune-mediated disorders

Original language	English
Pages (from-to)	114 - 116
Number of pages	3
Journal	Journal of Medical Genetics
Volume	45
Issue number	2
DOIs	https://doi.org/10.1136/jmg.2007.053595
Publication status	Published - Feb 2008

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Wolf, N., Quaranta, M., Prescott, N. J., Allen, M., Smith, R., Burden, A. D., Worthington, J., Griffiths, C. E. M., Mathew, C. G., Barker, J. N., Capon, F., & Trembath, R. C. (2008). Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease. Journal of Medical Genetics, 45(2), 114 - 116. https://doi.org/10.1136/jmg.2007.053595

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title = "Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease",

abstract = "Background: Psoriasis is an immune-mediated skin disorder that is inherited as a multifactorial trait. Linkage analyses have clearly mapped a primary disease susceptibility locus to the major histocompatibility complex (MHC) region on chromosome 6p21. More recently, whole-genome association studies have identified two non-MHC disease genes (IL12B and IL23R), both of which also confer susceptibility to Crohn disease (CD). Objective and methods: To ascertain the genetic overlap between these two inflammatory conditions further, we investigated 15 CD-associated loci in a psoriasis case-control dataset. Results: The analysis of 1256 patients and 2938 unrelated controls found significant associations for loci mapping to chromosomes 1q24 (rs12035082, p = 0.009), 6p22 (rs6908425, p = 0.00015) and 21q22 (rs2836754, p = 0.0003). Notably, the marker showing the strongest phenotypic effect (rs6908425) maps to CDKAL1, a gene also associated with type 2 diabetes. Conclusions: These results substantiate emerging evidence for a pleiotropic role for s genes that contribute to the pathogenesis of immune-mediated disorders",

author = "N Wolf and M Quaranta and Prescott, {N J} and M Allen and R Smith and Burden, {A D} and J Worthington and Griffiths, {C E M} and Mathew, {C G} and Barker, {J N} and F Capon and Trembath, {R C}",

year = "2008",

month = feb,

doi = "10.1136/jmg.2007.053595",

language = "English",

volume = "45",

pages = "114 -- 116",

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T1 - Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease

AU - Wolf, N

AU - Quaranta, M

AU - Prescott, N J

AU - Allen, M

AU - Smith, R

AU - Burden, A D

AU - Worthington, J

AU - Griffiths, C E M

AU - Mathew, C G

AU - Barker, J N

AU - Capon, F

AU - Trembath, R C

PY - 2008/2

Y1 - 2008/2

N2 - Background: Psoriasis is an immune-mediated skin disorder that is inherited as a multifactorial trait. Linkage analyses have clearly mapped a primary disease susceptibility locus to the major histocompatibility complex (MHC) region on chromosome 6p21. More recently, whole-genome association studies have identified two non-MHC disease genes (IL12B and IL23R), both of which also confer susceptibility to Crohn disease (CD). Objective and methods: To ascertain the genetic overlap between these two inflammatory conditions further, we investigated 15 CD-associated loci in a psoriasis case-control dataset. Results: The analysis of 1256 patients and 2938 unrelated controls found significant associations for loci mapping to chromosomes 1q24 (rs12035082, p = 0.009), 6p22 (rs6908425, p = 0.00015) and 21q22 (rs2836754, p = 0.0003). Notably, the marker showing the strongest phenotypic effect (rs6908425) maps to CDKAL1, a gene also associated with type 2 diabetes. Conclusions: These results substantiate emerging evidence for a pleiotropic role for s genes that contribute to the pathogenesis of immune-mediated disorders

AB - Background: Psoriasis is an immune-mediated skin disorder that is inherited as a multifactorial trait. Linkage analyses have clearly mapped a primary disease susceptibility locus to the major histocompatibility complex (MHC) region on chromosome 6p21. More recently, whole-genome association studies have identified two non-MHC disease genes (IL12B and IL23R), both of which also confer susceptibility to Crohn disease (CD). Objective and methods: To ascertain the genetic overlap between these two inflammatory conditions further, we investigated 15 CD-associated loci in a psoriasis case-control dataset. Results: The analysis of 1256 patients and 2938 unrelated controls found significant associations for loci mapping to chromosomes 1q24 (rs12035082, p = 0.009), 6p22 (rs6908425, p = 0.00015) and 21q22 (rs2836754, p = 0.0003). Notably, the marker showing the strongest phenotypic effect (rs6908425) maps to CDKAL1, a gene also associated with type 2 diabetes. Conclusions: These results substantiate emerging evidence for a pleiotropic role for s genes that contribute to the pathogenesis of immune-mediated disorders

U2 - 10.1136/jmg.2007.053595

DO - 10.1136/jmg.2007.053595

M3 - Article

SN - 1468-6244

VL - 45

SP - 114

EP - 116

JO - Journal of Medical Genetics

JF - Journal of Medical Genetics

IS - 2

ER -

Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease

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