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Psychiatric comorbidity as a risk factor for the mortality of people with bulimia nervosa

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Psychiatric comorbidity as a risk factor for the mortality of people with bulimia nervosa. / Himmerich, Hubertus; Hotopf, Matthew Hugo; Shetty, Hitesh; Schmidt, Ulrike Hermine; Treasure, Janet Linda; Hayes, Richard Derek; Stewart, Robert James; Chang, Chin-Kuo.

In: Social Psychiatry and Psychiatric Epidemiology, 04.02.2019.

Research output: Contribution to journalArticle

Harvard

Himmerich, H, Hotopf, MH, Shetty, H, Schmidt, UH, Treasure, JL, Hayes, RD, Stewart, RJ & Chang, C-K 2019, 'Psychiatric comorbidity as a risk factor for the mortality of people with bulimia nervosa', Social Psychiatry and Psychiatric Epidemiology.

APA

Himmerich, H., Hotopf, M. H., Shetty, H., Schmidt, U. H., Treasure, J. L., Hayes, R. D., ... Chang, C-K. (Accepted/In press). Psychiatric comorbidity as a risk factor for the mortality of people with bulimia nervosa. Social Psychiatry and Psychiatric Epidemiology.

Vancouver

Himmerich H, Hotopf MH, Shetty H, Schmidt UH, Treasure JL, Hayes RD et al. Psychiatric comorbidity as a risk factor for the mortality of people with bulimia nervosa. Social Psychiatry and Psychiatric Epidemiology. 2019 Feb 4.

Author

Himmerich, Hubertus ; Hotopf, Matthew Hugo ; Shetty, Hitesh ; Schmidt, Ulrike Hermine ; Treasure, Janet Linda ; Hayes, Richard Derek ; Stewart, Robert James ; Chang, Chin-Kuo. / Psychiatric comorbidity as a risk factor for the mortality of people with bulimia nervosa. In: Social Psychiatry and Psychiatric Epidemiology. 2019.

Bibtex Download

@article{33f4ef63ba43496c8e7524e6f9ed6152,
title = "Psychiatric comorbidity as a risk factor for the mortality of people with bulimia nervosa",
abstract = "Bulimia nervosa (BN) is associated with increased mortality. Frequent comorbidities of BN include substance use disorders, affective disorders and personality disorders (PD). These comorbidities may add an additional risk for mortality.We investigated the influence of these psychiatric comorbidities on all-cause mortality with demographic and socioeconomic factors considered as confounders over an observation period from January 2007 to March 2016 for 1,501 people with BN using anonymised health records data from the South London and Maudsley NHS Foundation Trust (SLaM), retrieved through its Clinical Records Interactive Search (CRIS) data resource. Mortality was ascertained through monthly linkages to the nationwide tracing system administered by the Office for National Statistics (ONS). We used Cox proportional hazards regression to calculate hazard ratios (HRs) with 95{\%} confidence intervals (CIs). Multivariable analyses were also performed to estimate effects when controlling for confounding of age, sex, ethnicity, borough, marital status and deprivation score. A total of 18 patients with BN died during the observation period. The standardized mortality ratio (SMR) for our study cohort (against the population of England and Wales in 2012 as a standard) was 2.52 (95{\%} CI: 1.49-3.97). Cox regressions revealed significant associations of mortality with older age and male gender. Comorbid PD (HR: 3.36; 95{\%} CI: 1.05-10.73) was significantly associated with all-cause mortality, even after controlling for demographic and socioeconomic covariates.These results highlight increased mortality in patients with BN and the importance of recognising and treating PDs in patients with BN.",
author = "Hubertus Himmerich and Hotopf, {Matthew Hugo} and Hitesh Shetty and Schmidt, {Ulrike Hermine} and Treasure, {Janet Linda} and Hayes, {Richard Derek} and Stewart, {Robert James} and Chin-Kuo Chang",
year = "2019",
month = "2",
day = "4",
language = "English",
journal = "Social Psychiatry and Psychiatric Epidemiology",
issn = "0933-7954",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Psychiatric comorbidity as a risk factor for the mortality of people with bulimia nervosa

AU - Himmerich, Hubertus

AU - Hotopf, Matthew Hugo

AU - Shetty, Hitesh

AU - Schmidt, Ulrike Hermine

AU - Treasure, Janet Linda

AU - Hayes, Richard Derek

AU - Stewart, Robert James

AU - Chang, Chin-Kuo

PY - 2019/2/4

Y1 - 2019/2/4

N2 - Bulimia nervosa (BN) is associated with increased mortality. Frequent comorbidities of BN include substance use disorders, affective disorders and personality disorders (PD). These comorbidities may add an additional risk for mortality.We investigated the influence of these psychiatric comorbidities on all-cause mortality with demographic and socioeconomic factors considered as confounders over an observation period from January 2007 to March 2016 for 1,501 people with BN using anonymised health records data from the South London and Maudsley NHS Foundation Trust (SLaM), retrieved through its Clinical Records Interactive Search (CRIS) data resource. Mortality was ascertained through monthly linkages to the nationwide tracing system administered by the Office for National Statistics (ONS). We used Cox proportional hazards regression to calculate hazard ratios (HRs) with 95% confidence intervals (CIs). Multivariable analyses were also performed to estimate effects when controlling for confounding of age, sex, ethnicity, borough, marital status and deprivation score. A total of 18 patients with BN died during the observation period. The standardized mortality ratio (SMR) for our study cohort (against the population of England and Wales in 2012 as a standard) was 2.52 (95% CI: 1.49-3.97). Cox regressions revealed significant associations of mortality with older age and male gender. Comorbid PD (HR: 3.36; 95% CI: 1.05-10.73) was significantly associated with all-cause mortality, even after controlling for demographic and socioeconomic covariates.These results highlight increased mortality in patients with BN and the importance of recognising and treating PDs in patients with BN.

AB - Bulimia nervosa (BN) is associated with increased mortality. Frequent comorbidities of BN include substance use disorders, affective disorders and personality disorders (PD). These comorbidities may add an additional risk for mortality.We investigated the influence of these psychiatric comorbidities on all-cause mortality with demographic and socioeconomic factors considered as confounders over an observation period from January 2007 to March 2016 for 1,501 people with BN using anonymised health records data from the South London and Maudsley NHS Foundation Trust (SLaM), retrieved through its Clinical Records Interactive Search (CRIS) data resource. Mortality was ascertained through monthly linkages to the nationwide tracing system administered by the Office for National Statistics (ONS). We used Cox proportional hazards regression to calculate hazard ratios (HRs) with 95% confidence intervals (CIs). Multivariable analyses were also performed to estimate effects when controlling for confounding of age, sex, ethnicity, borough, marital status and deprivation score. A total of 18 patients with BN died during the observation period. The standardized mortality ratio (SMR) for our study cohort (against the population of England and Wales in 2012 as a standard) was 2.52 (95% CI: 1.49-3.97). Cox regressions revealed significant associations of mortality with older age and male gender. Comorbid PD (HR: 3.36; 95% CI: 1.05-10.73) was significantly associated with all-cause mortality, even after controlling for demographic and socioeconomic covariates.These results highlight increased mortality in patients with BN and the importance of recognising and treating PDs in patients with BN.

M3 - Article

JO - Social Psychiatry and Psychiatric Epidemiology

JF - Social Psychiatry and Psychiatric Epidemiology

SN - 0933-7954

ER -

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