Psychometric properties of the Affective Lability Scale (54 and 18-item version) in patients with bipolar disorder, first-degree relatives, and healthy controls

Monica Aas; Geir Pedersen; Chantal Henry; Thomas Bjella; Frank Bellivier; Marion Leboyer; Jean Pierre Kahn; Renaud F. Cohen; Sebastien Gard; Sofie R. Aminoff; Trine V. Lagerberg; Ole A. Andreassen; Ingrid Melle; Bruno Etain

doi:10.1016/j.jad.2014.10.028

Psychometric properties of the Affective Lability Scale (54 and 18-item version) in patients with bipolar disorder, first-degree relatives, and healthy controls

Monica Aas^*, Geir Pedersen, Chantal Henry, Thomas Bjella, Frank Bellivier, Marion Leboyer, Jean Pierre Kahn, Renaud F. Cohen, Sebastien Gard, Sofie R. Aminoff, Trine V. Lagerberg, Ole A. Andreassen, Ingrid Melle, Bruno Etain

^*Corresponding author for this work

Social Genetic & Developmental Psychiatry

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

Introduction The aim of this study was to investigate the psychometric properties of the original 54 item version (ALS-54) and the short 18 item version (ALS-18) of the Affective Lability Scale (ALS) in patients with bipolar disorders, their first-degree relatives and healthy controls. Internal Consistency and Confirmatory Factor Analysis were performed, comparing clinical and non-clinical group comparisons on ALS scores. Methods A total of 993 participants (patients with bipolar disorders [n=422], first-degree relatives [n=201] and controls [n=370]) were recruited from France and Norway. Diagnosis and clinical characteristics were assessed using the Structured Clinical Interview for DSM-IV Axis I disorders (SCID-I), or the Diagnostic Interview for Genetic Studies (DIGS). Affective lability was measured using the ALS-54 and ALS-18. Results Both ALS-54 and ALS-18 showed high internal consistency, but the subdimensions of both versions were highly inter-correlated. From confirmatory factor analysis both versions revealed acceptable to good model fit. Patients had significantly higher ALS scores compared to controls, with affected first-degree relatives presenting intermediate scores. Conclusion Both the original ALS-54 version and the short ALS-18 version showed good psychometric properties. They also discriminated between patients with a bipolar disorder (high ALS), first degree relatives (intermediate ALS), and healthy controls (low ALS). A high correlation between ALS items for both versions was observed. Our study supports reducing the scale from 54 to 18 items.

Original language	English
Pages (from-to)	375-380
Number of pages	6
Journal	Journal of Affective Disorders
Volume	172
DOIs	https://doi.org/10.1016/j.jad.2014.10.028
Publication status	Published - 1 Feb 2015

Keywords

ALS original 54 item version (ALS-54)
ALS short 18 item version (ALS-18)
Bipolar disorders
First-degree relatives
Healthy controls
Psychometric properties

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10.1016/j.jad.2014.10.028

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Aas, M., Pedersen, G., Henry, C., Bjella, T., Bellivier, F., Leboyer, M., Kahn, J. P., Cohen, R. F., Gard, S., Aminoff, S. R., Lagerberg, T. V., Andreassen, O. A., Melle, I., & Etain, B. (2015). Psychometric properties of the Affective Lability Scale (54 and 18-item version) in patients with bipolar disorder, first-degree relatives, and healthy controls. Journal of Affective Disorders, 172, 375-380. https://doi.org/10.1016/j.jad.2014.10.028

@article{e32f3202b858453b871ba3d30d6ad5b9,

title = "Psychometric properties of the Affective Lability Scale (54 and 18-item version) in patients with bipolar disorder, first-degree relatives, and healthy controls",

abstract = "Introduction The aim of this study was to investigate the psychometric properties of the original 54 item version (ALS-54) and the short 18 item version (ALS-18) of the Affective Lability Scale (ALS) in patients with bipolar disorders, their first-degree relatives and healthy controls. Internal Consistency and Confirmatory Factor Analysis were performed, comparing clinical and non-clinical group comparisons on ALS scores. Methods A total of 993 participants (patients with bipolar disorders [n=422], first-degree relatives [n=201] and controls [n=370]) were recruited from France and Norway. Diagnosis and clinical characteristics were assessed using the Structured Clinical Interview for DSM-IV Axis I disorders (SCID-I), or the Diagnostic Interview for Genetic Studies (DIGS). Affective lability was measured using the ALS-54 and ALS-18. Results Both ALS-54 and ALS-18 showed high internal consistency, but the subdimensions of both versions were highly inter-correlated. From confirmatory factor analysis both versions revealed acceptable to good model fit. Patients had significantly higher ALS scores compared to controls, with affected first-degree relatives presenting intermediate scores. Conclusion Both the original ALS-54 version and the short ALS-18 version showed good psychometric properties. They also discriminated between patients with a bipolar disorder (high ALS), first degree relatives (intermediate ALS), and healthy controls (low ALS). A high correlation between ALS items for both versions was observed. Our study supports reducing the scale from 54 to 18 items.",

keywords = "ALS original 54 item version (ALS-54), ALS short 18 item version (ALS-18), Bipolar disorders, First-degree relatives, Healthy controls, Psychometric properties",

author = "Monica Aas and Geir Pedersen and Chantal Henry and Thomas Bjella and Frank Bellivier and Marion Leboyer and Kahn, {Jean Pierre} and Cohen, {Renaud F.} and Sebastien Gard and Aminoff, {Sofie R.} and Lagerberg, {Trine V.} and Andreassen, {Ole A.} and Ingrid Melle and Bruno Etain",

note = "Funding Information: France: This work was supported by INSERM (C0829), Assistance Publique – H{\^o}pitaux de Paris (P111002), ENBREC (European Network of Bipolar Research Expert Centre) (FP7-Health 223102), RTRS Sant{\'e} Mentale (Fondation Fondamental) and LABEX BioPsy (ANR-11-IDEX-0004-02), Agence Nationale pour la Recherche (ANR) (MANAGE_BD), Fondation pour la Recherche sur le Cerveau (FRC) and National Alliance for Research on Schizophrenia and Depression (NARSAD) . These organizations had no role in the design of the study, the collection, analysis and interpretation of data, the writing of the report and in the decision to submit the paper for publication. Norway: This study was funded by grants from the University of Oslo, South-Eastern Norway Health Authority ( #2013123 , #2006258 ), the Research Council of Norway ( #213837 , #223273 , #190311/V50 ) and the KG Jebsen Foundation . Publisher Copyright: {\textcopyright} 2014 Elsevier B.V. All rights reserved.",

year = "2015",

month = feb,

day = "1",

doi = "10.1016/j.jad.2014.10.028",

language = "English",

volume = "172",

pages = "375--380",

journal = "Journal of Affective Disorders",

issn = "0165-0327",

publisher = "Elsevier",

}

Aas, M, Pedersen, G, Henry, C, Bjella, T, Bellivier, F, Leboyer, M, Kahn, JP, Cohen, RF, Gard, S, Aminoff, SR, Lagerberg, TV, Andreassen, OA, Melle, I & Etain, B 2015, 'Psychometric properties of the Affective Lability Scale (54 and 18-item version) in patients with bipolar disorder, first-degree relatives, and healthy controls', Journal of Affective Disorders, vol. 172, pp. 375-380. https://doi.org/10.1016/j.jad.2014.10.028

TY - JOUR

T1 - Psychometric properties of the Affective Lability Scale (54 and 18-item version) in patients with bipolar disorder, first-degree relatives, and healthy controls

AU - Aas, Monica

AU - Pedersen, Geir

AU - Henry, Chantal

AU - Bjella, Thomas

AU - Bellivier, Frank

AU - Leboyer, Marion

AU - Kahn, Jean Pierre

AU - Cohen, Renaud F.

AU - Gard, Sebastien

AU - Aminoff, Sofie R.

AU - Lagerberg, Trine V.

AU - Andreassen, Ole A.

AU - Melle, Ingrid

AU - Etain, Bruno

N1 - Funding Information: France: This work was supported by INSERM (C0829), Assistance Publique – Hôpitaux de Paris (P111002), ENBREC (European Network of Bipolar Research Expert Centre) (FP7-Health 223102), RTRS Santé Mentale (Fondation Fondamental) and LABEX BioPsy (ANR-11-IDEX-0004-02), Agence Nationale pour la Recherche (ANR) (MANAGE_BD), Fondation pour la Recherche sur le Cerveau (FRC) and National Alliance for Research on Schizophrenia and Depression (NARSAD) . These organizations had no role in the design of the study, the collection, analysis and interpretation of data, the writing of the report and in the decision to submit the paper for publication. Norway: This study was funded by grants from the University of Oslo, South-Eastern Norway Health Authority ( #2013123 , #2006258 ), the Research Council of Norway ( #213837 , #223273 , #190311/V50 ) and the KG Jebsen Foundation . Publisher Copyright: © 2014 Elsevier B.V. All rights reserved.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Introduction The aim of this study was to investigate the psychometric properties of the original 54 item version (ALS-54) and the short 18 item version (ALS-18) of the Affective Lability Scale (ALS) in patients with bipolar disorders, their first-degree relatives and healthy controls. Internal Consistency and Confirmatory Factor Analysis were performed, comparing clinical and non-clinical group comparisons on ALS scores. Methods A total of 993 participants (patients with bipolar disorders [n=422], first-degree relatives [n=201] and controls [n=370]) were recruited from France and Norway. Diagnosis and clinical characteristics were assessed using the Structured Clinical Interview for DSM-IV Axis I disorders (SCID-I), or the Diagnostic Interview for Genetic Studies (DIGS). Affective lability was measured using the ALS-54 and ALS-18. Results Both ALS-54 and ALS-18 showed high internal consistency, but the subdimensions of both versions were highly inter-correlated. From confirmatory factor analysis both versions revealed acceptable to good model fit. Patients had significantly higher ALS scores compared to controls, with affected first-degree relatives presenting intermediate scores. Conclusion Both the original ALS-54 version and the short ALS-18 version showed good psychometric properties. They also discriminated between patients with a bipolar disorder (high ALS), first degree relatives (intermediate ALS), and healthy controls (low ALS). A high correlation between ALS items for both versions was observed. Our study supports reducing the scale from 54 to 18 items.

AB - Introduction The aim of this study was to investigate the psychometric properties of the original 54 item version (ALS-54) and the short 18 item version (ALS-18) of the Affective Lability Scale (ALS) in patients with bipolar disorders, their first-degree relatives and healthy controls. Internal Consistency and Confirmatory Factor Analysis were performed, comparing clinical and non-clinical group comparisons on ALS scores. Methods A total of 993 participants (patients with bipolar disorders [n=422], first-degree relatives [n=201] and controls [n=370]) were recruited from France and Norway. Diagnosis and clinical characteristics were assessed using the Structured Clinical Interview for DSM-IV Axis I disorders (SCID-I), or the Diagnostic Interview for Genetic Studies (DIGS). Affective lability was measured using the ALS-54 and ALS-18. Results Both ALS-54 and ALS-18 showed high internal consistency, but the subdimensions of both versions were highly inter-correlated. From confirmatory factor analysis both versions revealed acceptable to good model fit. Patients had significantly higher ALS scores compared to controls, with affected first-degree relatives presenting intermediate scores. Conclusion Both the original ALS-54 version and the short ALS-18 version showed good psychometric properties. They also discriminated between patients with a bipolar disorder (high ALS), first degree relatives (intermediate ALS), and healthy controls (low ALS). A high correlation between ALS items for both versions was observed. Our study supports reducing the scale from 54 to 18 items.

KW - ALS original 54 item version (ALS-54)

KW - ALS short 18 item version (ALS-18)

KW - Bipolar disorders

KW - First-degree relatives

KW - Healthy controls

KW - Psychometric properties

UR - http://www.scopus.com/inward/record.url?scp=84913572982&partnerID=8YFLogxK

U2 - 10.1016/j.jad.2014.10.028

DO - 10.1016/j.jad.2014.10.028

M3 - Article

C2 - 25451440

AN - SCOPUS:84913572982

SN - 0165-0327

VL - 172

SP - 375

EP - 380

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

ER -

Psychometric properties of the Affective Lability Scale (54 and 18-item version) in patients with bipolar disorder, first-degree relatives, and healthy controls

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Keywords

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