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Psychometric properties of the German version of the Leicester Cough Questionnaire in sarcoidosis

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Jonas Christian Schupp, Urs Alexander Fichtner, Bjoèrn Christian Frye, Katja Heyduck-Weides, Surinder S. Birring, Wolfram Windisch, Carl Peter Criée, Joachim Müller-Quernheim, Erik Farin

Original languageEnglish
Article numbere0205308
JournalPLoS ONE
Issue number10
Accepted/In press21 Sep 2018
Published1 Oct 2018


King's Authors


Background Cough is one of the most common symptoms in general and pulmonary medicine with profound negative impact on health-related quality of life (HRQL). The Leicester Cough Questionnaire (LCQ) is a validated HRQL questionnaire, yet a validated German version of the LCQ is not available and it has never been tested in a cohort with sarcoidosis. Objectives To translate the LCQ into German and determine its psychometric properties. Methods The LCQ was translated in a forward-backward approach. Structured interviews in sarcoidosis patients were performed. Subsequently, sarcoidosis patients were asked to answer the German LCQ and comparative questionnaires. Distribution properties, item difficulty, concurrent validity, Rasch model fit and internal consistency of the German LCQ were determined. Results 200 patients with sarcoidosis were included. We provide evidence for reliability, unidimensionality and internal consistency. However, only a moderate correlation with general and respiratory-specific HRQL questionnaires, no Rasch model fit could be shown. Skewed responses caused by floor effects were detected. Conclusion We demonstrate that the German LCQ is valid and reliable and its psychometric properties fulfil the standards required for its use in clinical settings as well as in interventional trials.

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