The associations between hormonal changes and psychiatric disorders have long been recognized, but only in recent decades have the underlying mechanisms begun to be understood. A renewed interest in the associations linking stressful early life events, hypothalamic-pituitary-adrenal (HPA) axis dysregulation, inflammatory processes, and potential vulnerability to depression, psychosis, and posttraumatic stress disorder (PTSD) has prompted a resurgence of research in this field. Although the association between reproductive hormone changes and psychiatric disorders has been less well studied, there is likewise a growing clinical recognition of the burden of postpartum psychopathology and a new impetus for research progress in this area. A full account of how each endocrine system influences neurobehavioral function is beyond the scope of a single chapter; we focus here on summarizing the most firmly established findings from classic literature in the field, and on providing an overview of some recent promising research findings.
Original languageEnglish
Title of host publicationThe American Psychiatric Association Publishing Textbook of Psychopharmacology
Subtitle of host publicationFifth Edition
EditorsAlan F. Schatzberg, Charles B. Nemeroff
ISBN (Electronic)9781615371228
Publication statusPublished - 1 May 2017


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