King's College London

Research portal


Research output: Chapter in Book/Report/Conference proceedingChapter

Original languageEnglish
Title of host publicationThe American Psychiatric Association Publishing Textbook of Psychopharmacology
Subtitle of host publicationFifth Edition
EditorsAlan F. Schatzberg, Charles B. Nemeroff
ISBN (Electronic)9781615371228
Publication statusPublished - 1 May 2017

King's Authors


The associations between hormonal changes and psychiatric disorders have long been recognized, but only in recent decades have the underlying mechanisms begun to be understood. A renewed interest in the associations linking stressful early life events, hypothalamic-pituitary-adrenal (HPA) axis dysregulation, inflammatory processes, and potential vulnerability to depression, psychosis, and posttraumatic stress disorder (PTSD) has prompted a resurgence of research in this field. Although the association between reproductive hormone changes and psychiatric disorders has been less well studied, there is likewise a growing clinical recognition of the burden of postpartum psychopathology and a new impetus for research progress in this area. A full account of how each endocrine system influences neurobehavioral function is beyond the scope of a single chapter; we focus here on summarizing the most firmly established findings from classic literature in the field, and on providing an overview of some recent promising research findings.

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454