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Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation

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Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation. / for the IMAGEN Consortium.

In: Translational psychiatry, Vol. 9, No. 1, 103, 25.02.2019.

Research output: Contribution to journalArticle

Harvard

for the IMAGEN Consortium 2019, 'Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation', Translational psychiatry, vol. 9, no. 1, 103. https://doi.org/10.1038/s41398-019-0433-6

APA

for the IMAGEN Consortium (2019). Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation. Translational psychiatry, 9(1), [103]. https://doi.org/10.1038/s41398-019-0433-6

Vancouver

for the IMAGEN Consortium. Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation. Translational psychiatry. 2019 Feb 25;9(1). 103. https://doi.org/10.1038/s41398-019-0433-6

Author

for the IMAGEN Consortium. / Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation. In: Translational psychiatry. 2019 ; Vol. 9, No. 1.

Bibtex Download

@article{109a6d2e074e4511bcd02eedd15e109d,
title = "Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation",
abstract = "This study examines the effects of puberty and sex on the intrinsic functional connectivity (iFC) of brain networks, with a focus on the default-mode network (DMN). Consistently implicated in depressive disorders, the DMN’s function may interact with puberty and sex in the development of these disorders, whose onsets peak in adolescence, and which show strong sex disproportionality (females > males). The main question concerns how the DMN evolves with puberty as a function of sex. These effects are expected to involve within- and between-network iFC, particularly, the salience and the central-executive networks, consistent with the Triple-Network Model. Resting-state scans of an adolescent community sample (n = 304, male/female: 157/147; mean/std age: 14.6/0.41 years), from the IMAGEN database, were analyzed using the AFNI software suite and a data reduction strategy for the effects of puberty and sex. Three midline regions (medial prefrontal, pregenual anterior cingulate, and posterior cingulate), within the DMN and consistently implicated in mood disorders, were selected as seeds. Within- and between-network clusters of the DMN iFC changed with pubertal maturation differently in boys and girls (puberty-X-sex). Specifically, pubertal maturation predicted weaker iFC in girls and stronger iFC in boys. Finally, iFC was stronger in boys than girls independently of puberty. Brain–behavior associations indicated that lower connectivity of the anterior cingulate seed predicted higher internalizing symptoms at 2-year follow-up. In conclusion, weaker iFC of the anterior DMN may signal disconnections among circuits supporting mood regulation, conferring risk for internalizing disorders.",
author = "{for the IMAGEN Consortium} and Monique Ernst and Brenda Benson and Eric Artiges and Gorka, {Adam X.} and Herve Lemaitre and Tiffany Lago and Ruben Miranda and Tobias Banaschewski and Bokde, {Arun L.W.} and Uli Bromberg and R{\"u}diger Br{\"u}hl and Christian B{\"u}chel and Anna Cattrell and Patricia Conrod and Sylvane Desrivi{\`e}res and Tahmine Fadai and Herta Flor and Antoine Grigis and Juergen Gallinat and Hugh Garavan and Penny Gowland and Yvonne Grimmer and Andreas Heinz and Viola Kappel and Frauke Nees and Dimitri Papadopoulos-Orfanos and Jani Penttil{\"a} and Luise Poustka and Smolka, {Michael N.} and Argyris Stringaris and Maren Struve and {van Noort}, {Betteke M.} and Henrik Walter and Robert Whelan and Gunter Schumann and D. Theobald and Barker, {G. J.} and J. Reuter and J. Ireland and J. Rogers and D. Hall and T. Jia and C. Mallik and C. Nymberg and B. Ruggeri and L. Smith and L. Topper and H. Werts and J. Jones and C. Newman",
year = "2019",
month = "2",
day = "25",
doi = "10.1038/s41398-019-0433-6",
language = "English",
volume = "9",
journal = "Translational psychiatry",
issn = "2158-3188",
publisher = "Nature Publishing Group",
number = "1",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation

AU - for the IMAGEN Consortium

AU - Ernst, Monique

AU - Benson, Brenda

AU - Artiges, Eric

AU - Gorka, Adam X.

AU - Lemaitre, Herve

AU - Lago, Tiffany

AU - Miranda, Ruben

AU - Banaschewski, Tobias

AU - Bokde, Arun L.W.

AU - Bromberg, Uli

AU - Brühl, Rüdiger

AU - Büchel, Christian

AU - Cattrell, Anna

AU - Conrod, Patricia

AU - Desrivières, Sylvane

AU - Fadai, Tahmine

AU - Flor, Herta

AU - Grigis, Antoine

AU - Gallinat, Juergen

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Grimmer, Yvonne

AU - Heinz, Andreas

AU - Kappel, Viola

AU - Nees, Frauke

AU - Papadopoulos-Orfanos, Dimitri

AU - Penttilä, Jani

AU - Poustka, Luise

AU - Smolka, Michael N.

AU - Stringaris, Argyris

AU - Struve, Maren

AU - van Noort, Betteke M.

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

AU - Theobald, D.

AU - Barker, G. J.

AU - Reuter, J.

AU - Ireland, J.

AU - Rogers, J.

AU - Hall, D.

AU - Jia, T.

AU - Mallik, C.

AU - Nymberg, C.

AU - Ruggeri, B.

AU - Smith, L.

AU - Topper, L.

AU - Werts, H.

AU - Jones, J.

AU - Newman, C.

PY - 2019/2/25

Y1 - 2019/2/25

N2 - This study examines the effects of puberty and sex on the intrinsic functional connectivity (iFC) of brain networks, with a focus on the default-mode network (DMN). Consistently implicated in depressive disorders, the DMN’s function may interact with puberty and sex in the development of these disorders, whose onsets peak in adolescence, and which show strong sex disproportionality (females > males). The main question concerns how the DMN evolves with puberty as a function of sex. These effects are expected to involve within- and between-network iFC, particularly, the salience and the central-executive networks, consistent with the Triple-Network Model. Resting-state scans of an adolescent community sample (n = 304, male/female: 157/147; mean/std age: 14.6/0.41 years), from the IMAGEN database, were analyzed using the AFNI software suite and a data reduction strategy for the effects of puberty and sex. Three midline regions (medial prefrontal, pregenual anterior cingulate, and posterior cingulate), within the DMN and consistently implicated in mood disorders, were selected as seeds. Within- and between-network clusters of the DMN iFC changed with pubertal maturation differently in boys and girls (puberty-X-sex). Specifically, pubertal maturation predicted weaker iFC in girls and stronger iFC in boys. Finally, iFC was stronger in boys than girls independently of puberty. Brain–behavior associations indicated that lower connectivity of the anterior cingulate seed predicted higher internalizing symptoms at 2-year follow-up. In conclusion, weaker iFC of the anterior DMN may signal disconnections among circuits supporting mood regulation, conferring risk for internalizing disorders.

AB - This study examines the effects of puberty and sex on the intrinsic functional connectivity (iFC) of brain networks, with a focus on the default-mode network (DMN). Consistently implicated in depressive disorders, the DMN’s function may interact with puberty and sex in the development of these disorders, whose onsets peak in adolescence, and which show strong sex disproportionality (females > males). The main question concerns how the DMN evolves with puberty as a function of sex. These effects are expected to involve within- and between-network iFC, particularly, the salience and the central-executive networks, consistent with the Triple-Network Model. Resting-state scans of an adolescent community sample (n = 304, male/female: 157/147; mean/std age: 14.6/0.41 years), from the IMAGEN database, were analyzed using the AFNI software suite and a data reduction strategy for the effects of puberty and sex. Three midline regions (medial prefrontal, pregenual anterior cingulate, and posterior cingulate), within the DMN and consistently implicated in mood disorders, were selected as seeds. Within- and between-network clusters of the DMN iFC changed with pubertal maturation differently in boys and girls (puberty-X-sex). Specifically, pubertal maturation predicted weaker iFC in girls and stronger iFC in boys. Finally, iFC was stronger in boys than girls independently of puberty. Brain–behavior associations indicated that lower connectivity of the anterior cingulate seed predicted higher internalizing symptoms at 2-year follow-up. In conclusion, weaker iFC of the anterior DMN may signal disconnections among circuits supporting mood regulation, conferring risk for internalizing disorders.

UR - http://www.scopus.com/inward/record.url?scp=85062069450&partnerID=8YFLogxK

U2 - 10.1038/s41398-019-0433-6

DO - 10.1038/s41398-019-0433-6

M3 - Article

C2 - 30804326

AN - SCOPUS:85062069450

VL - 9

JO - Translational psychiatry

JF - Translational psychiatry

SN - 2158-3188

IS - 1

M1 - 103

ER -

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