Pulmonary vascular changes in asthma and COPD

Louise M. Harkness, Varsha Kanabar, Hari S. Sharma, Gunilla Westergren-Thorsson, Anna Karin Larsson-Callerfelt*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)

Abstract

In chronic lung disorders such as in asthma and chronic obstructive pulmonary disease (COPD) there is increased bronchial angiogenesis and remodelling of pulmonary vessels culminating to altered bronchial and pulmonary circulation. The involvement of residential cells such as endothelial cells, smooth muscle cells and pulmonary fibroblasts, all appear to have a crucial role in the progression of vascular inflammation and remodelling. The regulatory abnormalities, growth factors and mediators implicated in the pulmonary vascular changes of asthma and COPD subjects and potential therapeutic targets have been described in this review.

Original languageEnglish
Pages (from-to)144-155
Number of pages12
JournalPulmonary pharmacology & therapeutics
Volume29
Issue number2
DOIs
Publication statusPublished - 2014

Keywords

  • Airway smooth muscle
  • Angiogenesis
  • Asthma
  • COPD
  • Pulmonary fibroblast
  • Vascular endothelial growth factor

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