QTc interval in a sample of long-term schizophrenia inpatients

Ramón Ramos-Ríos; Manuel Arrojo-Romero; Eduardo Paz-Silva; Fernando Carballal-Calvo; José L Bouzón-Barreiro; Jorge Seoane-Prado; Rosario Codesido-Barcala; Alicia Crespí-Armenteros; Ramón Fernández-Pérez; Javier D López-Moríñigo; Ignacio Tortajada-Bonaselt; Francisco J Diaz; Jose de Leon

doi:10.1016/j.schres.2009.09.041

QTc interval in a sample of long-term schizophrenia inpatients

Ramón Ramos-Ríos, Manuel Arrojo-Romero, Eduardo Paz-Silva, Fernando Carballal-Calvo, José L Bouzón-Barreiro, Jorge Seoane-Prado, Rosario Codesido-Barcala, Alicia Crespí-Armenteros, Ramón Fernández-Pérez, Javier D López-Moríñigo, Ignacio Tortajada-Bonaselt, Francisco J Diaz, Jose de Leon

Psychosis Studies

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

This naturalistic study attempted to determine the prevalence of prolonged QTc interval in a relatively large population of inpatients hospitalized with chronic schizophrenia, and to explore QTc relationship with demographic variables, metabolic parameters and prescribed treatments. All inpatients from a Spanish long-term psychiatric hospital were cross-sectionally investigated to determine the prevalence of QTc prolongation and metabolic syndrome. The sample with a DSM-IV diagnosis of schizophrenia included 171 Caucasian inpatients, all of Spanish origin. A prolonged QTc interval was defined as >450 ms in men and >470 ms in women. The relationships between QTc and other continuous variables were assessed using a linear regression model with QTc as the dependent variable. Only 10 patients (6%) had a prolonged QTc interval; one case was possibly explained by hypokalemia. Three patients (2%) had a QTc > 500 ms. Gender, old age (> or = 50 years old), current smoking, systolic blood pressure, HDL cholesterol and history of arrhythmia were found to have significant effects on QTc interval in a linear regression analysis. After controlling for significant variables, the mean QTc interval was not significantly influenced by antipsychotic dose, type of antipsychotic treatment, the use of depot antipsychotics, or the number of different antipsychotics prescribed. Our study focused on long-term schizophrenia inpatients with frequent antipsychotic polypharmacy and high antipsychotic doses, and suggested that after excluding the case with hypokalemia length of QTc was associated with history of arrhythmias and with metabolic factors, while the effects of antipsychotic compound or class were not so evident.

Original language	English
Pages (from-to)	35-43
Number of pages	9
Journal	Schizophrenia Research
Volume	116
Issue number	1
DOIs	https://doi.org/10.1016/j.schres.2009.09.041
Publication status	Published - Jan 2010

Keywords

Adult
Age Factors
Aged
Analysis of Variance
Antipsychotic Agents
Body Mass Index
Electrocardiography
Female
Heart Rate
Humans
Inpatients
Long QT Syndrome
Male
Middle Aged
Potassium
Prevalence
Regression Analysis
Schizophrenia
Sex Factors

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10.1016/j.schres.2009.09.041

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Ramos-Ríos, R., Arrojo-Romero, M., Paz-Silva, E., Carballal-Calvo, F., Bouzón-Barreiro, J. L., Seoane-Prado, J., Codesido-Barcala, R., Crespí-Armenteros, A., Fernández-Pérez, R., López-Moríñigo, J. D., Tortajada-Bonaselt, I., Diaz, F. J., & de Leon, J. (2010). QTc interval in a sample of long-term schizophrenia inpatients. Schizophrenia Research, 116(1), 35-43. https://doi.org/10.1016/j.schres.2009.09.041

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title = "QTc interval in a sample of long-term schizophrenia inpatients",

abstract = "This naturalistic study attempted to determine the prevalence of prolonged QTc interval in a relatively large population of inpatients hospitalized with chronic schizophrenia, and to explore QTc relationship with demographic variables, metabolic parameters and prescribed treatments. All inpatients from a Spanish long-term psychiatric hospital were cross-sectionally investigated to determine the prevalence of QTc prolongation and metabolic syndrome. The sample with a DSM-IV diagnosis of schizophrenia included 171 Caucasian inpatients, all of Spanish origin. A prolonged QTc interval was defined as >450 ms in men and >470 ms in women. The relationships between QTc and other continuous variables were assessed using a linear regression model with QTc as the dependent variable. Only 10 patients (6%) had a prolonged QTc interval; one case was possibly explained by hypokalemia. Three patients (2%) had a QTc > 500 ms. Gender, old age (> or = 50 years old), current smoking, systolic blood pressure, HDL cholesterol and history of arrhythmia were found to have significant effects on QTc interval in a linear regression analysis. After controlling for significant variables, the mean QTc interval was not significantly influenced by antipsychotic dose, type of antipsychotic treatment, the use of depot antipsychotics, or the number of different antipsychotics prescribed. Our study focused on long-term schizophrenia inpatients with frequent antipsychotic polypharmacy and high antipsychotic doses, and suggested that after excluding the case with hypokalemia length of QTc was associated with history of arrhythmias and with metabolic factors, while the effects of antipsychotic compound or class were not so evident.",

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author = "Ram{\'o}n Ramos-R{\'i}os and Manuel Arrojo-Romero and Eduardo Paz-Silva and Fernando Carballal-Calvo and Bouz{\'o}n-Barreiro, {Jos{\'e} L} and Jorge Seoane-Prado and Rosario Codesido-Barcala and Alicia Cresp{\'i}-Armenteros and Ram{\'o}n Fern{\'a}ndez-P{\'e}rez and L{\'o}pez-Mor{\'i}{\~n}igo, {Javier D} and Ignacio Tortajada-Bonaselt and Diaz, {Francisco J} and {de Leon}, Jose",

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doi = "10.1016/j.schres.2009.09.041",

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Ramos-Ríos, R, Arrojo-Romero, M, Paz-Silva, E, Carballal-Calvo, F, Bouzón-Barreiro, JL, Seoane-Prado, J, Codesido-Barcala, R, Crespí-Armenteros, A, Fernández-Pérez, R, López-Moríñigo, JD, Tortajada-Bonaselt, I, Diaz, FJ & de Leon, J 2010, 'QTc interval in a sample of long-term schizophrenia inpatients', Schizophrenia Research, vol. 116, no. 1, pp. 35-43. https://doi.org/10.1016/j.schres.2009.09.041

TY - JOUR

T1 - QTc interval in a sample of long-term schizophrenia inpatients

AU - Ramos-Ríos, Ramón

AU - Arrojo-Romero, Manuel

AU - Paz-Silva, Eduardo

AU - Carballal-Calvo, Fernando

AU - Bouzón-Barreiro, José L

AU - Seoane-Prado, Jorge

AU - Codesido-Barcala, Rosario

AU - Crespí-Armenteros, Alicia

AU - Fernández-Pérez, Ramón

AU - López-Moríñigo, Javier D

AU - Tortajada-Bonaselt, Ignacio

AU - Diaz, Francisco J

AU - de Leon, Jose

PY - 2010/1

Y1 - 2010/1

N2 - This naturalistic study attempted to determine the prevalence of prolonged QTc interval in a relatively large population of inpatients hospitalized with chronic schizophrenia, and to explore QTc relationship with demographic variables, metabolic parameters and prescribed treatments. All inpatients from a Spanish long-term psychiatric hospital were cross-sectionally investigated to determine the prevalence of QTc prolongation and metabolic syndrome. The sample with a DSM-IV diagnosis of schizophrenia included 171 Caucasian inpatients, all of Spanish origin. A prolonged QTc interval was defined as >450 ms in men and >470 ms in women. The relationships between QTc and other continuous variables were assessed using a linear regression model with QTc as the dependent variable. Only 10 patients (6%) had a prolonged QTc interval; one case was possibly explained by hypokalemia. Three patients (2%) had a QTc > 500 ms. Gender, old age (> or = 50 years old), current smoking, systolic blood pressure, HDL cholesterol and history of arrhythmia were found to have significant effects on QTc interval in a linear regression analysis. After controlling for significant variables, the mean QTc interval was not significantly influenced by antipsychotic dose, type of antipsychotic treatment, the use of depot antipsychotics, or the number of different antipsychotics prescribed. Our study focused on long-term schizophrenia inpatients with frequent antipsychotic polypharmacy and high antipsychotic doses, and suggested that after excluding the case with hypokalemia length of QTc was associated with history of arrhythmias and with metabolic factors, while the effects of antipsychotic compound or class were not so evident.

AB - This naturalistic study attempted to determine the prevalence of prolonged QTc interval in a relatively large population of inpatients hospitalized with chronic schizophrenia, and to explore QTc relationship with demographic variables, metabolic parameters and prescribed treatments. All inpatients from a Spanish long-term psychiatric hospital were cross-sectionally investigated to determine the prevalence of QTc prolongation and metabolic syndrome. The sample with a DSM-IV diagnosis of schizophrenia included 171 Caucasian inpatients, all of Spanish origin. A prolonged QTc interval was defined as >450 ms in men and >470 ms in women. The relationships between QTc and other continuous variables were assessed using a linear regression model with QTc as the dependent variable. Only 10 patients (6%) had a prolonged QTc interval; one case was possibly explained by hypokalemia. Three patients (2%) had a QTc > 500 ms. Gender, old age (> or = 50 years old), current smoking, systolic blood pressure, HDL cholesterol and history of arrhythmia were found to have significant effects on QTc interval in a linear regression analysis. After controlling for significant variables, the mean QTc interval was not significantly influenced by antipsychotic dose, type of antipsychotic treatment, the use of depot antipsychotics, or the number of different antipsychotics prescribed. Our study focused on long-term schizophrenia inpatients with frequent antipsychotic polypharmacy and high antipsychotic doses, and suggested that after excluding the case with hypokalemia length of QTc was associated with history of arrhythmias and with metabolic factors, while the effects of antipsychotic compound or class were not so evident.

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KW - Age Factors

KW - Aged

KW - Analysis of Variance

KW - Antipsychotic Agents

KW - Body Mass Index

KW - Electrocardiography

KW - Female

KW - Heart Rate

KW - Humans

KW - Inpatients

KW - Long QT Syndrome

KW - Male

KW - Middle Aged

KW - Potassium

KW - Prevalence

KW - Regression Analysis

KW - Schizophrenia

KW - Sex Factors

U2 - 10.1016/j.schres.2009.09.041

DO - 10.1016/j.schres.2009.09.041

M3 - Article

C2 - 19892525

SN - 0920-9964

VL - 116

SP - 35

EP - 43

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1

ER -

QTc interval in a sample of long-term schizophrenia inpatients

Abstract

Keywords

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