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Qualitative differences in the spatiotemporal brain states supporting configural face processing emerge in adolescence in autism

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Qualitative differences in the spatiotemporal brain states supporting configural face processing emerge in adolescence in autism. / The EU-AIMS LEAP Group.

In: Cortex, Vol. 155, 10.2022, p. 13-29.

Research output: Contribution to journalArticlepeer-review

Harvard

The EU-AIMS LEAP Group 2022, 'Qualitative differences in the spatiotemporal brain states supporting configural face processing emerge in adolescence in autism', Cortex, vol. 155, pp. 13-29. https://doi.org/10.1016/j.cortex.2022.06.010

APA

The EU-AIMS LEAP Group (2022). Qualitative differences in the spatiotemporal brain states supporting configural face processing emerge in adolescence in autism. Cortex, 155, 13-29. https://doi.org/10.1016/j.cortex.2022.06.010

Vancouver

The EU-AIMS LEAP Group. Qualitative differences in the spatiotemporal brain states supporting configural face processing emerge in adolescence in autism. Cortex. 2022 Oct;155:13-29. https://doi.org/10.1016/j.cortex.2022.06.010

Author

The EU-AIMS LEAP Group. / Qualitative differences in the spatiotemporal brain states supporting configural face processing emerge in adolescence in autism. In: Cortex. 2022 ; Vol. 155. pp. 13-29.

Bibtex Download

@article{123fdfdf57994c86b20187d6b5ff69c4,
title = "Qualitative differences in the spatiotemporal brain states supporting configural face processing emerge in adolescence in autism",
abstract = "Background: Studying the neural processing of faces can illuminate the mechanisms of compromised social expertise in autism. To resolve a longstanding debate, we examined whether differences in configural face processing in autism are underpinned by quantitative differences in the activation of typical face processing pathways, or the recruitment of non-typical neural systems. Methods: We investigated spatial and temporal characteristics of event-related EEG responses to upright and inverted faces in a large sample of children, adolescents, and adults with and without autism. We examined topographic analyses of variance and global field power to identify group differences in the spatial and temporal response to face inversion. We then examined how quasi-stable spatiotemporal profiles – microstates – are modulated by face orientation and diagnostic group. Results: Upright and inverted faces produced distinct profiles of topography and strength in the topographical analyses. These topographical profiles differed between diagnostic groups in adolescents, but not in children or adults. In the microstate analysis, the autistic group showed differences in the activation strength of normative microstates during early-stage processing at all ages, suggesting consistent quantitative differences in the operation of typical processing pathways; qualitative differences in microstate topographies during late-stage processing became prominent in adults, suggesting the increasing involvement of non-typical neural systems with processing time and over development. Conclusions: These findings suggest that early difficulties with configural face processing may trigger later compensatory processes in autism that emerge in later development.",
keywords = "Autism, Development, EEG, Face inversion effect, Face processing",
author = "{The EU-AIMS LEAP Group} and Rianne Haartsen and Luke Mason and Pilar Garces and Anna Gui and Tony Charman and Julian Tillmann and Johnson, {Mark H.} and Buitelaar, {Jan K.} and Eva Loth and Declan Murphy and Jones, {Emily J.H.} and Jumana Ahmad and Sara Ambrosino and Tobias Banashewski and Simon Baron-Cohen and Nico Bast and Sarah Baumeister and Christian Beckmann and Sven B{\"o}lte and Thomas Bourgeron and Carsten Bours and Daniel Brandeis and Ineke Cornelissen and Daisy Crawley and Cate Davidson and {Dell{\textquoteright} Acqua}, Flavio and Sarah Durston and Christine Ecker and Claire Ellis and Jessica Faulkner and Hannah Hayward and Joerg Hipp and Rosemary Holt and Lai, {Meng Chuan} and Claire Leblond and Andreas Meyer-Lindenberg and Carolin Moessnang and Bethany Oakley and Larry O'Dwyer and Antonio Persico and Annika Rausch and Jessica Sabet and {San Jose Caceres}, Antonia and Emily Simonoff and Heike Tost and Rhein, {Daniel von}",
note = "Funding Information: This work was supported by EU-AIMS (European Autism Interventions), which received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no. 115300, the resources of which are composed of financial contributions from the European Union{\textquoteright} s Seventh Framework Programme (grant FP7/2007–2013), from the European Federation of Pharmaceutical Industries and Associations companies{\textquoteright} in-kind contributions, and from Autism Speaks as well as AIMS-2-TRIALS which received support from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 777394. This joint undertaking receives support from the European Union's Horizon 2020 research and innovation programme and EFPIA and AUTISM SPEAKS, Autistica, SFARI. Disclaimer: The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. Any views expressed are those of the author(s) and not necessarily those of the funders. Funding Information: This work has further been supported by the UK Medical Research Council [grant number G0701484 & MR/K021389/1 ](MJ/EJ), and Economic and Social Research Council [grant number ES/R009368/1](EJ), and the Horizon 2020 programme of the European Union [CANDY project, grant number 847818 ](JB). Publisher Copyright: {\textcopyright} 2022 The Author(s)",
year = "2022",
month = oct,
doi = "10.1016/j.cortex.2022.06.010",
language = "English",
volume = "155",
pages = "13--29",
journal = "Cortex; a journal devoted to the study of the nervous system and behavior",
issn = "0010-9452",
publisher = "Elsevier Masson",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Qualitative differences in the spatiotemporal brain states supporting configural face processing emerge in adolescence in autism

AU - The EU-AIMS LEAP Group

AU - Haartsen, Rianne

AU - Mason, Luke

AU - Garces, Pilar

AU - Gui, Anna

AU - Charman, Tony

AU - Tillmann, Julian

AU - Johnson, Mark H.

AU - Buitelaar, Jan K.

AU - Loth, Eva

AU - Murphy, Declan

AU - Jones, Emily J.H.

AU - Ahmad, Jumana

AU - Ambrosino, Sara

AU - Banashewski, Tobias

AU - Baron-Cohen, Simon

AU - Bast, Nico

AU - Baumeister, Sarah

AU - Beckmann, Christian

AU - Bölte, Sven

AU - Bourgeron, Thomas

AU - Bours, Carsten

AU - Brandeis, Daniel

AU - Cornelissen, Ineke

AU - Crawley, Daisy

AU - Davidson, Cate

AU - Dell’ Acqua, Flavio

AU - Durston, Sarah

AU - Ecker, Christine

AU - Ellis, Claire

AU - Faulkner, Jessica

AU - Hayward, Hannah

AU - Hipp, Joerg

AU - Holt, Rosemary

AU - Lai, Meng Chuan

AU - Leblond, Claire

AU - Meyer-Lindenberg, Andreas

AU - Moessnang, Carolin

AU - Oakley, Bethany

AU - O'Dwyer, Larry

AU - Persico, Antonio

AU - Rausch, Annika

AU - Sabet, Jessica

AU - San Jose Caceres, Antonia

AU - Simonoff, Emily

AU - Tost, Heike

AU - Rhein, Daniel von

N1 - Funding Information: This work was supported by EU-AIMS (European Autism Interventions), which received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no. 115300, the resources of which are composed of financial contributions from the European Union’ s Seventh Framework Programme (grant FP7/2007–2013), from the European Federation of Pharmaceutical Industries and Associations companies’ in-kind contributions, and from Autism Speaks as well as AIMS-2-TRIALS which received support from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 777394. This joint undertaking receives support from the European Union's Horizon 2020 research and innovation programme and EFPIA and AUTISM SPEAKS, Autistica, SFARI. Disclaimer: The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. Any views expressed are those of the author(s) and not necessarily those of the funders. Funding Information: This work has further been supported by the UK Medical Research Council [grant number G0701484 & MR/K021389/1 ](MJ/EJ), and Economic and Social Research Council [grant number ES/R009368/1](EJ), and the Horizon 2020 programme of the European Union [CANDY project, grant number 847818 ](JB). Publisher Copyright: © 2022 The Author(s)

PY - 2022/10

Y1 - 2022/10

N2 - Background: Studying the neural processing of faces can illuminate the mechanisms of compromised social expertise in autism. To resolve a longstanding debate, we examined whether differences in configural face processing in autism are underpinned by quantitative differences in the activation of typical face processing pathways, or the recruitment of non-typical neural systems. Methods: We investigated spatial and temporal characteristics of event-related EEG responses to upright and inverted faces in a large sample of children, adolescents, and adults with and without autism. We examined topographic analyses of variance and global field power to identify group differences in the spatial and temporal response to face inversion. We then examined how quasi-stable spatiotemporal profiles – microstates – are modulated by face orientation and diagnostic group. Results: Upright and inverted faces produced distinct profiles of topography and strength in the topographical analyses. These topographical profiles differed between diagnostic groups in adolescents, but not in children or adults. In the microstate analysis, the autistic group showed differences in the activation strength of normative microstates during early-stage processing at all ages, suggesting consistent quantitative differences in the operation of typical processing pathways; qualitative differences in microstate topographies during late-stage processing became prominent in adults, suggesting the increasing involvement of non-typical neural systems with processing time and over development. Conclusions: These findings suggest that early difficulties with configural face processing may trigger later compensatory processes in autism that emerge in later development.

AB - Background: Studying the neural processing of faces can illuminate the mechanisms of compromised social expertise in autism. To resolve a longstanding debate, we examined whether differences in configural face processing in autism are underpinned by quantitative differences in the activation of typical face processing pathways, or the recruitment of non-typical neural systems. Methods: We investigated spatial and temporal characteristics of event-related EEG responses to upright and inverted faces in a large sample of children, adolescents, and adults with and without autism. We examined topographic analyses of variance and global field power to identify group differences in the spatial and temporal response to face inversion. We then examined how quasi-stable spatiotemporal profiles – microstates – are modulated by face orientation and diagnostic group. Results: Upright and inverted faces produced distinct profiles of topography and strength in the topographical analyses. These topographical profiles differed between diagnostic groups in adolescents, but not in children or adults. In the microstate analysis, the autistic group showed differences in the activation strength of normative microstates during early-stage processing at all ages, suggesting consistent quantitative differences in the operation of typical processing pathways; qualitative differences in microstate topographies during late-stage processing became prominent in adults, suggesting the increasing involvement of non-typical neural systems with processing time and over development. Conclusions: These findings suggest that early difficulties with configural face processing may trigger later compensatory processes in autism that emerge in later development.

KW - Autism

KW - Development

KW - EEG

KW - Face inversion effect

KW - Face processing

UR - http://www.scopus.com/inward/record.url?scp=85135710911&partnerID=8YFLogxK

U2 - 10.1016/j.cortex.2022.06.010

DO - 10.1016/j.cortex.2022.06.010

M3 - Article

AN - SCOPUS:85135710911

VL - 155

SP - 13

EP - 29

JO - Cortex; a journal devoted to the study of the nervous system and behavior

JF - Cortex; a journal devoted to the study of the nervous system and behavior

SN - 0010-9452

ER -

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