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Qualitative Phenotyping of Obstructive Sleep Apnea and its Clinical Usefulness for the Sleep Specialist

Research output: Contribution to journalArticle

Marcello Bosi, Andrea de Vito, Danny Eckert, Joerg Steier, Bhik Kotecha, Claudio Vicini, Venerino Poletti

Original languageEnglish
Article numberijerph-718586
JournalInternational Journal of Environmental Research and Public Health
Publication statusAccepted/In press - 16 Mar 2020

King's Authors

Abstract

Introduction: The object of this study is the analysis of a model of qualitative phenotypization to characterize the different pathophysiological traits in patients with Obstructive sleep apnea syndrome (OSA), using clinical polysomnography, and underlying its importance for the sleep specialist during daily clinical practice. Methods: A systematic review were performed from 1983 to 2018, to analyze available peer-reviewed evidence to generate a model of qualitative phenotypization to characterize pathophysiological traits in patients with OSA, using clinical and polysomnographic parameters. Results: 96 out of 3829 abstracts were selected for full-text review. Upper airway anatomical collapsibility, neuromuscular tone and function, sleep-wake and ventilatory control instability, as well as the arousal threshold all interact and contribute to certain pathophysiologic features that characterize different types of OSA. Discussion: Accurate identification of OSA pathophysiological traits requires quite complex in-laboratory procedures. The analysis of available peer-reviewed evidence allows to generate a model of qualitative phenotypization to characterize pathophysiological traits in patients with OSA, using clinical and polysomnographic parameters. Conclusion: The clinical and polygraphic OSA phenotypization is of particular interest for the sleep specialist during daily clinical practice, surgical treatment decision-making and OSA customized multimodality treatment.

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