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Quality of surgical care can impact survival in patients with bladder cancer after robot-assisted radical cystectomy: results from the International Robotic Cystectomy Consortium

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Quality of surgical care can impact survival in patients with bladder cancer after robot-assisted radical cystectomy : results from the International Robotic Cystectomy Consortium. / Ahmed, Youssef; Hussein, Ahmed A.; May, Paul R.; Ahmad, Basel; Khan, Amir; Benkowski, John; Durrani, Ayesha; Khan, Saira; Kozlowski, Justen; Saar, Matthias; Wijburg, Carl J.; Richstone, Lee; Wagner, Andrew; Yuh, Bertram; Redorta, Joan Palou; Dasgupta, Prokar; Khan, Mohammad Shamim; Menon, Mani; Peabody, James O.; Hosseini, Abolfazl; Gaboardi, Franco; Pini, Giovannalberto; Schanne, Francis; Mottrie, Alexandre; Rha, Koon ho; Hemal, Ashok; Stockle, Michael; Kelly, John; Tan, Wei Shen; Maatman, Thomas J.; Poulakis, Vassilis; Kaouk, Jihad; Canda, Abdullah Erdem; Balbay, Mevlana Derya; Wiklund, Peter; Guru, Khurshid A.

In: African Journal of Urology, Vol. 26, No. 1, 22, 01.12.2020.

Research output: Contribution to journalArticle

Harvard

Ahmed, Y, Hussein, AA, May, PR, Ahmad, B, Khan, A, Benkowski, J, Durrani, A, Khan, S, Kozlowski, J, Saar, M, Wijburg, CJ, Richstone, L, Wagner, A, Yuh, B, Redorta, JP, Dasgupta, P, Khan, MS, Menon, M, Peabody, JO, Hosseini, A, Gaboardi, F, Pini, G, Schanne, F, Mottrie, A, Rha, KH, Hemal, A, Stockle, M, Kelly, J, Tan, WS, Maatman, TJ, Poulakis, V, Kaouk, J, Canda, AE, Balbay, MD, Wiklund, P & Guru, KA 2020, 'Quality of surgical care can impact survival in patients with bladder cancer after robot-assisted radical cystectomy: results from the International Robotic Cystectomy Consortium', African Journal of Urology, vol. 26, no. 1, 22. https://doi.org/10.1186/s12301-020-00031-y

APA

Ahmed, Y., Hussein, A. A., May, P. R., Ahmad, B., Khan, A., Benkowski, J., Durrani, A., Khan, S., Kozlowski, J., Saar, M., Wijburg, C. J., Richstone, L., Wagner, A., Yuh, B., Redorta, J. P., Dasgupta, P., Khan, M. S., Menon, M., Peabody, J. O., ... Guru, K. A. (2020). Quality of surgical care can impact survival in patients with bladder cancer after robot-assisted radical cystectomy: results from the International Robotic Cystectomy Consortium. African Journal of Urology, 26(1), [22]. https://doi.org/10.1186/s12301-020-00031-y

Vancouver

Ahmed Y, Hussein AA, May PR, Ahmad B, Khan A, Benkowski J et al. Quality of surgical care can impact survival in patients with bladder cancer after robot-assisted radical cystectomy: results from the International Robotic Cystectomy Consortium. African Journal of Urology. 2020 Dec 1;26(1). 22. https://doi.org/10.1186/s12301-020-00031-y

Author

Ahmed, Youssef ; Hussein, Ahmed A. ; May, Paul R. ; Ahmad, Basel ; Khan, Amir ; Benkowski, John ; Durrani, Ayesha ; Khan, Saira ; Kozlowski, Justen ; Saar, Matthias ; Wijburg, Carl J. ; Richstone, Lee ; Wagner, Andrew ; Yuh, Bertram ; Redorta, Joan Palou ; Dasgupta, Prokar ; Khan, Mohammad Shamim ; Menon, Mani ; Peabody, James O. ; Hosseini, Abolfazl ; Gaboardi, Franco ; Pini, Giovannalberto ; Schanne, Francis ; Mottrie, Alexandre ; Rha, Koon ho ; Hemal, Ashok ; Stockle, Michael ; Kelly, John ; Tan, Wei Shen ; Maatman, Thomas J. ; Poulakis, Vassilis ; Kaouk, Jihad ; Canda, Abdullah Erdem ; Balbay, Mevlana Derya ; Wiklund, Peter ; Guru, Khurshid A. / Quality of surgical care can impact survival in patients with bladder cancer after robot-assisted radical cystectomy : results from the International Robotic Cystectomy Consortium. In: African Journal of Urology. 2020 ; Vol. 26, No. 1.

Bibtex Download

@article{6ec0717939384a20882a6f835630f1aa,
title = "Quality of surgical care can impact survival in patients with bladder cancer after robot-assisted radical cystectomy: results from the International Robotic Cystectomy Consortium",
abstract = "Background: Although pathological factors remain the main determinate of survival for patients with bladder cancer, quality of surgical care is crucial for satisfactory outcomes. Using a validated quality score, we investigated the impact of surgical factors on the overall survival (OS), recurrence-free survival (RFS) and disease-specific survival (DSS) in patients with locally advanced and organ-confined disease (OCD). Retrospective review of IRCC database includes 2460 patients from 29 institutions across 11 countries. The final cohort included 1343 patients who underwent RARCs between 2005 and 2016. Patients with locally advanced disease (LAD) (> pT2 and/or N +) were compared with OCD (≤ pT2/N0). Validated Quality Cystectomy Score (QCS) based on four sets of quality metrics was used to compare surgical performance. Kaplan–Meier method was used to compute RFS, CSS and OS rates. Multivariable stepwise logistic regression was used to evaluate variables associated with RFS, DSS and OS. Results: 48% had LAD. When compared to patients with OCD, they received neobladders less frequently (17% vs. 28%, p < 0.001) and experienced higher estimated blood loss (513 vs. 376 ml, p = 0.05). Postoperatively, more patients in the LAD group received adjuvant chemotherapy (24% vs. 4%, p < 0.001) and positive surgical margins (14% vs. 2%, p < 0.001) and had higher 90-day mortality (6% vs. 2%, p < 0.001). On multivariable analysis, female gender, higher QCS score, intracorporeal diversion, pT stage, positive lymph node status and recurrence are considered as predictors of survival. Patients with OCD exhibited better RFS, DSS and OS than patients with LAD. For patients with OCD, higher QCS was associated with improved OS but not RFS or DSS. On the other hand, patients with LAD and higher QCS exhibited higher RFS, DSS and OS when compared to those with lower QCS. Conclusion: Quality of surgical care can affect disease control and OS in patients with bladder cancer treated with robot-assisted radical cystectomy.",
keywords = "Bladder cancer, Cystectomy, Locally advanced, Organ confined, Quality, Robotic",
author = "Youssef Ahmed and Hussein, {Ahmed A.} and May, {Paul R.} and Basel Ahmad and Amir Khan and John Benkowski and Ayesha Durrani and Saira Khan and Justen Kozlowski and Matthias Saar and Wijburg, {Carl J.} and Lee Richstone and Andrew Wagner and Bertram Yuh and Redorta, {Joan Palou} and Prokar Dasgupta and Khan, {Mohammad Shamim} and Mani Menon and Peabody, {James O.} and Abolfazl Hosseini and Franco Gaboardi and Giovannalberto Pini and Francis Schanne and Alexandre Mottrie and Rha, {Koon ho} and Ashok Hemal and Michael Stockle and John Kelly and Tan, {Wei Shen} and Maatman, {Thomas J.} and Vassilis Poulakis and Jihad Kaouk and Canda, {Abdullah Erdem} and Balbay, {Mevlana Derya} and Peter Wiklund and Guru, {Khurshid A.}",
year = "2020",
month = dec,
day = "1",
doi = "10.1186/s12301-020-00031-y",
language = "English",
volume = "26",
journal = "African Journal of Urology",
issn = "1110-5704",
publisher = "Pan African Urological Surgeons' Association (PAUSA)",
number = "1",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Quality of surgical care can impact survival in patients with bladder cancer after robot-assisted radical cystectomy

T2 - results from the International Robotic Cystectomy Consortium

AU - Ahmed, Youssef

AU - Hussein, Ahmed A.

AU - May, Paul R.

AU - Ahmad, Basel

AU - Khan, Amir

AU - Benkowski, John

AU - Durrani, Ayesha

AU - Khan, Saira

AU - Kozlowski, Justen

AU - Saar, Matthias

AU - Wijburg, Carl J.

AU - Richstone, Lee

AU - Wagner, Andrew

AU - Yuh, Bertram

AU - Redorta, Joan Palou

AU - Dasgupta, Prokar

AU - Khan, Mohammad Shamim

AU - Menon, Mani

AU - Peabody, James O.

AU - Hosseini, Abolfazl

AU - Gaboardi, Franco

AU - Pini, Giovannalberto

AU - Schanne, Francis

AU - Mottrie, Alexandre

AU - Rha, Koon ho

AU - Hemal, Ashok

AU - Stockle, Michael

AU - Kelly, John

AU - Tan, Wei Shen

AU - Maatman, Thomas J.

AU - Poulakis, Vassilis

AU - Kaouk, Jihad

AU - Canda, Abdullah Erdem

AU - Balbay, Mevlana Derya

AU - Wiklund, Peter

AU - Guru, Khurshid A.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Background: Although pathological factors remain the main determinate of survival for patients with bladder cancer, quality of surgical care is crucial for satisfactory outcomes. Using a validated quality score, we investigated the impact of surgical factors on the overall survival (OS), recurrence-free survival (RFS) and disease-specific survival (DSS) in patients with locally advanced and organ-confined disease (OCD). Retrospective review of IRCC database includes 2460 patients from 29 institutions across 11 countries. The final cohort included 1343 patients who underwent RARCs between 2005 and 2016. Patients with locally advanced disease (LAD) (> pT2 and/or N +) were compared with OCD (≤ pT2/N0). Validated Quality Cystectomy Score (QCS) based on four sets of quality metrics was used to compare surgical performance. Kaplan–Meier method was used to compute RFS, CSS and OS rates. Multivariable stepwise logistic regression was used to evaluate variables associated with RFS, DSS and OS. Results: 48% had LAD. When compared to patients with OCD, they received neobladders less frequently (17% vs. 28%, p < 0.001) and experienced higher estimated blood loss (513 vs. 376 ml, p = 0.05). Postoperatively, more patients in the LAD group received adjuvant chemotherapy (24% vs. 4%, p < 0.001) and positive surgical margins (14% vs. 2%, p < 0.001) and had higher 90-day mortality (6% vs. 2%, p < 0.001). On multivariable analysis, female gender, higher QCS score, intracorporeal diversion, pT stage, positive lymph node status and recurrence are considered as predictors of survival. Patients with OCD exhibited better RFS, DSS and OS than patients with LAD. For patients with OCD, higher QCS was associated with improved OS but not RFS or DSS. On the other hand, patients with LAD and higher QCS exhibited higher RFS, DSS and OS when compared to those with lower QCS. Conclusion: Quality of surgical care can affect disease control and OS in patients with bladder cancer treated with robot-assisted radical cystectomy.

AB - Background: Although pathological factors remain the main determinate of survival for patients with bladder cancer, quality of surgical care is crucial for satisfactory outcomes. Using a validated quality score, we investigated the impact of surgical factors on the overall survival (OS), recurrence-free survival (RFS) and disease-specific survival (DSS) in patients with locally advanced and organ-confined disease (OCD). Retrospective review of IRCC database includes 2460 patients from 29 institutions across 11 countries. The final cohort included 1343 patients who underwent RARCs between 2005 and 2016. Patients with locally advanced disease (LAD) (> pT2 and/or N +) were compared with OCD (≤ pT2/N0). Validated Quality Cystectomy Score (QCS) based on four sets of quality metrics was used to compare surgical performance. Kaplan–Meier method was used to compute RFS, CSS and OS rates. Multivariable stepwise logistic regression was used to evaluate variables associated with RFS, DSS and OS. Results: 48% had LAD. When compared to patients with OCD, they received neobladders less frequently (17% vs. 28%, p < 0.001) and experienced higher estimated blood loss (513 vs. 376 ml, p = 0.05). Postoperatively, more patients in the LAD group received adjuvant chemotherapy (24% vs. 4%, p < 0.001) and positive surgical margins (14% vs. 2%, p < 0.001) and had higher 90-day mortality (6% vs. 2%, p < 0.001). On multivariable analysis, female gender, higher QCS score, intracorporeal diversion, pT stage, positive lymph node status and recurrence are considered as predictors of survival. Patients with OCD exhibited better RFS, DSS and OS than patients with LAD. For patients with OCD, higher QCS was associated with improved OS but not RFS or DSS. On the other hand, patients with LAD and higher QCS exhibited higher RFS, DSS and OS when compared to those with lower QCS. Conclusion: Quality of surgical care can affect disease control and OS in patients with bladder cancer treated with robot-assisted radical cystectomy.

KW - Bladder cancer

KW - Cystectomy

KW - Locally advanced

KW - Organ confined

KW - Quality

KW - Robotic

UR - http://www.scopus.com/inward/record.url?scp=85086574810&partnerID=8YFLogxK

U2 - 10.1186/s12301-020-00031-y

DO - 10.1186/s12301-020-00031-y

M3 - Article

AN - SCOPUS:85086574810

VL - 26

JO - African Journal of Urology

JF - African Journal of Urology

SN - 1110-5704

IS - 1

M1 - 22

ER -

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