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Quantification of [18F]UCB-H Binding in the Rat Brain: From Kinetic Modelling to Standardised Uptake Value

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Quantification of [18F]UCB-H Binding in the Rat Brain : From Kinetic Modelling to Standardised Uptake Value. / Serrano, Maria Elisa; Bahri, Mohamed Ali; Becker, Guillaume; Seret, Alain; Mievis, Frédéric; Giacomelli, Fabrice; Lemaire, Christian; Salmon, Eric; Luxen, André; Plenevaux, Alain.

In: Molecular Imaging and Biology, Vol. 21, No. 5, 10.2019, p. 888-897.

Research output: Contribution to journalArticlepeer-review

Harvard

Serrano, ME, Bahri, MA, Becker, G, Seret, A, Mievis, F, Giacomelli, F, Lemaire, C, Salmon, E, Luxen, A & Plenevaux, A 2019, 'Quantification of [18F]UCB-H Binding in the Rat Brain: From Kinetic Modelling to Standardised Uptake Value', Molecular Imaging and Biology, vol. 21, no. 5, pp. 888-897. https://doi.org/10.1007/s11307-018-1301-0

APA

Serrano, M. E., Bahri, M. A., Becker, G., Seret, A., Mievis, F., Giacomelli, F., Lemaire, C., Salmon, E., Luxen, A., & Plenevaux, A. (2019). Quantification of [18F]UCB-H Binding in the Rat Brain: From Kinetic Modelling to Standardised Uptake Value. Molecular Imaging and Biology, 21(5), 888-897. https://doi.org/10.1007/s11307-018-1301-0

Vancouver

Serrano ME, Bahri MA, Becker G, Seret A, Mievis F, Giacomelli F et al. Quantification of [18F]UCB-H Binding in the Rat Brain: From Kinetic Modelling to Standardised Uptake Value. Molecular Imaging and Biology. 2019 Oct;21(5):888-897. https://doi.org/10.1007/s11307-018-1301-0

Author

Serrano, Maria Elisa ; Bahri, Mohamed Ali ; Becker, Guillaume ; Seret, Alain ; Mievis, Frédéric ; Giacomelli, Fabrice ; Lemaire, Christian ; Salmon, Eric ; Luxen, André ; Plenevaux, Alain. / Quantification of [18F]UCB-H Binding in the Rat Brain : From Kinetic Modelling to Standardised Uptake Value. In: Molecular Imaging and Biology. 2019 ; Vol. 21, No. 5. pp. 888-897.

Bibtex Download

@article{a44700dcbdb04b08a7caf695282ac3ff,
title = "Quantification of [18F]UCB-H Binding in the Rat Brain: From Kinetic Modelling to Standardised Uptake Value",
abstract = "PURPOSE: [18F]UCB-H is a specific positron emission tomography (PET) biomarker for the Synaptic Vesicle protein 2A (SV2A), the binding site of the antiepileptic drug levetiracetam. With a view to optimising acquisition time and simplifying data analysis with this radiotracer, we compared two parameters: the distribution volume (Vt) obtained from Logan graphical analysis using a Population-Based Input Function, and the Standardised Uptake Value (SUV).PROCEDURES: Twelve Sprague Dawley male rats, pre-treated with three different doses of levetiracetam were employed to develop the methodology. Three additional kainic acid (KA) treated rats (temporal lobe epilepsy model) were also used to test the procedure. Image analyses focused on: (i) length of the dynamic acquisition (90 versus 60 min); (ii) correlations between Vt and SUV over 20-min consecutive time-frames; (iii) and (iv) evaluation of differences between groups using the Vt and the SUV; and (v) preliminary evaluation of the methodology in the KA epilepsy model.RESULTS: A large correlation between the Vt issued from 60 to 90-min acquisitions was observed. Further analyses highlighted a large correlation (r > 0.8) between the Vt and the SUV. Equivalent differences between groups were detected for both parameters, especially in the 20-40 and 40-60-min time-frames. The same results were also obtained with the epilepsy model.CONCLUSIONS: Our results enable the acquisition setting to be changed from a 90-min dynamic to a 20-min static PET acquisition. According to a better image quality, the 20-40-min time-frame appears optimal. Due to its equivalence to the Vt, the SUV parameter can be considered in order to quantify [18F]UCB-H uptake in the rat brain. This work, therefore, establishes a starting point for the simplification of SV2A in vivo quantification with [18F]UCB-H, and represents a step forward to the clinical application of this PET radiotracer.",
author = "Serrano, {Maria Elisa} and Bahri, {Mohamed Ali} and Guillaume Becker and Alain Seret and Fr{\'e}d{\'e}ric Mievis and Fabrice Giacomelli and Christian Lemaire and Eric Salmon and Andr{\'e} Luxen and Alain Plenevaux",
year = "2019",
month = oct,
doi = "10.1007/s11307-018-1301-0",
language = "English",
volume = "21",
pages = "888--897",
journal = "Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging",
issn = "1536-1632",
publisher = "Springer",
number = "5",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Quantification of [18F]UCB-H Binding in the Rat Brain

T2 - From Kinetic Modelling to Standardised Uptake Value

AU - Serrano, Maria Elisa

AU - Bahri, Mohamed Ali

AU - Becker, Guillaume

AU - Seret, Alain

AU - Mievis, Frédéric

AU - Giacomelli, Fabrice

AU - Lemaire, Christian

AU - Salmon, Eric

AU - Luxen, André

AU - Plenevaux, Alain

PY - 2019/10

Y1 - 2019/10

N2 - PURPOSE: [18F]UCB-H is a specific positron emission tomography (PET) biomarker for the Synaptic Vesicle protein 2A (SV2A), the binding site of the antiepileptic drug levetiracetam. With a view to optimising acquisition time and simplifying data analysis with this radiotracer, we compared two parameters: the distribution volume (Vt) obtained from Logan graphical analysis using a Population-Based Input Function, and the Standardised Uptake Value (SUV).PROCEDURES: Twelve Sprague Dawley male rats, pre-treated with three different doses of levetiracetam were employed to develop the methodology. Three additional kainic acid (KA) treated rats (temporal lobe epilepsy model) were also used to test the procedure. Image analyses focused on: (i) length of the dynamic acquisition (90 versus 60 min); (ii) correlations between Vt and SUV over 20-min consecutive time-frames; (iii) and (iv) evaluation of differences between groups using the Vt and the SUV; and (v) preliminary evaluation of the methodology in the KA epilepsy model.RESULTS: A large correlation between the Vt issued from 60 to 90-min acquisitions was observed. Further analyses highlighted a large correlation (r > 0.8) between the Vt and the SUV. Equivalent differences between groups were detected for both parameters, especially in the 20-40 and 40-60-min time-frames. The same results were also obtained with the epilepsy model.CONCLUSIONS: Our results enable the acquisition setting to be changed from a 90-min dynamic to a 20-min static PET acquisition. According to a better image quality, the 20-40-min time-frame appears optimal. Due to its equivalence to the Vt, the SUV parameter can be considered in order to quantify [18F]UCB-H uptake in the rat brain. This work, therefore, establishes a starting point for the simplification of SV2A in vivo quantification with [18F]UCB-H, and represents a step forward to the clinical application of this PET radiotracer.

AB - PURPOSE: [18F]UCB-H is a specific positron emission tomography (PET) biomarker for the Synaptic Vesicle protein 2A (SV2A), the binding site of the antiepileptic drug levetiracetam. With a view to optimising acquisition time and simplifying data analysis with this radiotracer, we compared two parameters: the distribution volume (Vt) obtained from Logan graphical analysis using a Population-Based Input Function, and the Standardised Uptake Value (SUV).PROCEDURES: Twelve Sprague Dawley male rats, pre-treated with three different doses of levetiracetam were employed to develop the methodology. Three additional kainic acid (KA) treated rats (temporal lobe epilepsy model) were also used to test the procedure. Image analyses focused on: (i) length of the dynamic acquisition (90 versus 60 min); (ii) correlations between Vt and SUV over 20-min consecutive time-frames; (iii) and (iv) evaluation of differences between groups using the Vt and the SUV; and (v) preliminary evaluation of the methodology in the KA epilepsy model.RESULTS: A large correlation between the Vt issued from 60 to 90-min acquisitions was observed. Further analyses highlighted a large correlation (r > 0.8) between the Vt and the SUV. Equivalent differences between groups were detected for both parameters, especially in the 20-40 and 40-60-min time-frames. The same results were also obtained with the epilepsy model.CONCLUSIONS: Our results enable the acquisition setting to be changed from a 90-min dynamic to a 20-min static PET acquisition. According to a better image quality, the 20-40-min time-frame appears optimal. Due to its equivalence to the Vt, the SUV parameter can be considered in order to quantify [18F]UCB-H uptake in the rat brain. This work, therefore, establishes a starting point for the simplification of SV2A in vivo quantification with [18F]UCB-H, and represents a step forward to the clinical application of this PET radiotracer.

U2 - 10.1007/s11307-018-1301-0

DO - 10.1007/s11307-018-1301-0

M3 - Article

C2 - 30460626

VL - 21

SP - 888

EP - 897

JO - Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging

JF - Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging

SN - 1536-1632

IS - 5

ER -

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