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Quantifying adherence to antihypertensive medication for chronic hypertension during pregnancy

Research output: Contribution to journalArticle

Louise M. Webster, Kate Reed, Jenny E. Myers, Angela Burns, Pankaj Gupta, Prashnath Patel, Cornelia Wiesender, Paul T. Seed, Catherine Nelson-Piercy, Lucy C. Chappell

Original languageEnglish
Pages (from-to)12-14
Number of pages3
JournalPregnancy Hypertension
Early online date3 May 2019
Publication statusPublished - 1 Jul 2019


King's Authors


Estimates of adherence to antihypertensive treatment in pregnancy are limited; identifying non-adherence could facilitate intervention and optimise blood pressure control. This study aimed to evaluate adherence to antihypertensive treatment amongst pregnant women with chronic hypertension using high-performance liquid chromatography-tandem mass spectrometry instrumentation. Spot urine samples collected from women who were randomised to labetalol or nifedipine were assessed. Samples from 74 women were included; documented prescribing and urine metabolite detection were concordant in 88% (n = 65). Evidence of self-administration of alternative treatment was observed in 8% (n = 6). Measurement of urinary antihypertensive metabolites in pregnancy provides insight into treatment adherence.

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