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Quantifying the intra-operative hemodynamic effects of glue embolization in vein of Galen malformations

Research output: Contribution to journalArticlepeer-review

Premal A Patel, Dimitra Flouri, Adam Rennie, Fergus Robertson, Lauren Davies, Vijeya Ganesan, Sanjay Bhate, Paolo De Coppi, Tom Vercauteren, Andrew Melbourne

Original languageEnglish
Pages (from-to)754-758
Number of pages5
Journal2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)
Published1 Apr 2019
Event16th IEEE International Symposium on Biomedical Imaging, ISBI 2019 - Venice, Italy
Duration: 8 Apr 201911 Apr 2019

King's Authors


Vein of Galen malformation is a rare congenital pathological intracranial arteriovenous shunt which carries 30% risk of death before 28 days-of-age. Treatment is by high risk minimally invasive endovascular glue embolization of shunt feeding arteries under angiographic control. A tool to support intra-operative decision making would be useful. We present a novel method for visualizing angiography data to demonstrate the effect of the intervention based upon change the after embolization in the delay in time of peak contrast density relative to the injected artery and a novel method for quantifying the immediate effect of embolization on the hemodynamics of the shunt. The method is demonstrated on the angiograms of five neonates who underwent embolization. We show consistent results including a post-embolization increase in the delay in time of peak contrast density relative to the injected artery at the venous outflow in keeping with reduced shunting and redistribution of blood following embolization.

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