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Quantitative Fetal Fibronectin at 18 Weeks of Gestation to Predict Preterm Birth in Asymptomatic High-Risk Women

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Quantitative Fetal Fibronectin at 18 Weeks of Gestation to Predict Preterm Birth in Asymptomatic High-Risk Women. / Hezelgrave Elliott, Natasha; Abbott, Danielle S.; Radford, Samara K.; Seed, Paul T.; Girling, Joanna C.; Filmer, Judy; Tribe, Rachel M.; Shennan, Andrew H.

In: Obstetrics and Gynecology, Vol. 127, No. 2, 01.02.2016, p. 255-263.

Research output: Contribution to journalArticle

Harvard

Hezelgrave Elliott, N, Abbott, DS, Radford, SK, Seed, PT, Girling, JC, Filmer, J, Tribe, RM & Shennan, AH 2016, 'Quantitative Fetal Fibronectin at 18 Weeks of Gestation to Predict Preterm Birth in Asymptomatic High-Risk Women', Obstetrics and Gynecology, vol. 127, no. 2, pp. 255-263. https://doi.org/10.1097/AOG.0000000000001240

APA

Hezelgrave Elliott, N., Abbott, D. S., Radford, S. K., Seed, P. T., Girling, J. C., Filmer, J., Tribe, R. M., & Shennan, A. H. (2016). Quantitative Fetal Fibronectin at 18 Weeks of Gestation to Predict Preterm Birth in Asymptomatic High-Risk Women. Obstetrics and Gynecology, 127(2), 255-263. https://doi.org/10.1097/AOG.0000000000001240

Vancouver

Hezelgrave Elliott N, Abbott DS, Radford SK, Seed PT, Girling JC, Filmer J et al. Quantitative Fetal Fibronectin at 18 Weeks of Gestation to Predict Preterm Birth in Asymptomatic High-Risk Women. Obstetrics and Gynecology. 2016 Feb 1;127(2):255-263. https://doi.org/10.1097/AOG.0000000000001240

Author

Hezelgrave Elliott, Natasha ; Abbott, Danielle S. ; Radford, Samara K. ; Seed, Paul T. ; Girling, Joanna C. ; Filmer, Judy ; Tribe, Rachel M. ; Shennan, Andrew H. / Quantitative Fetal Fibronectin at 18 Weeks of Gestation to Predict Preterm Birth in Asymptomatic High-Risk Women. In: Obstetrics and Gynecology. 2016 ; Vol. 127, No. 2. pp. 255-263.

Bibtex Download

@article{f21f0def6b264eaa91dede5412071d27,
title = "Quantitative Fetal Fibronectin at 18 Weeks of Gestation to Predict Preterm Birth in Asymptomatic High-Risk Women",
abstract = "OBJECTIVE: To compare quantitative fetal fibronectin measurement from 18 to 21 weeks of gestation to measurement at 22-27 weeks of gestation for the prediction of spontaneous preterm birth. METHODS: In a prospective cohort study, we studied the accuracy of cervicovaginal fluid quantitative fetal fibronectin concentrations measured between 18 0/7 weeks of gestation and 21 6/7 weeks of gestation in high-risk asymptomatic women to predict spontaneous preterm birth before 34 weeks of gestation. Predefined fibronectin thresholds were 10 or greater, 50 or greater, and 200 ng/mL or greater. Diagnostic accuracy of the early test (n898) was compared with the standard test performed between 22 0/7 and 27 6/7 weeks of gestation (n691) in the same cohort. Subgroup analysis was performed according to cervical length measurement. RESULTS: Of 898 women, 8.7% delivered spontaneously before 34 weeks of gestation. Only 3.8% of the women with concentrations less than 10 ng/mL (65% of test results) delivered before 34 weeks of gestation. A concentration threshold of 10 ng/mL measured at 18 and 22 weeks of gestation had comparably high sensitivity (early 0.71, 95% confidence interval 0.60-0.81; standard 0.76, 0.63-0.87) and negative predictive value (early 0.96, 0.94-0.98; standard 0.97, 0.95-0.99) for delivery before 34 weeks of gestation. Specificity was also comparable (early 0.69, 0.65-0.72; standard 0.70, 0.66-0.74). A threshold of 200 ng/mL had high specificity (early 0.96, 0.94-0.98; standard 0.96, 0.94-0.97) with lower sensitivity (early 0.26, 0.17-0.37; standard 0.35, 0.22-0.49). Consideration of cervical length strengthened prediction. CONCLUSION: Quantitative cervicovaginal fetal fibronectin measured from 18 to 21 weeks of gestation has similar predictive value as measurement at 22-27 weeks of gestation for prediction of spontaneous preterm birth. Low fibronectin concentrations are associated with spontaneous preterm birthrates approaching population background levels.",
author = "{Hezelgrave Elliott}, Natasha and Abbott, {Danielle S.} and Radford, {Samara K.} and Seed, {Paul T.} and Girling, {Joanna C.} and Judy Filmer and Tribe, {Rachel M.} and Shennan, {Andrew H.}",
year = "2016",
month = feb,
day = "1",
doi = "10.1097/AOG.0000000000001240",
language = "English",
volume = "127",
pages = "255--263",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Quantitative Fetal Fibronectin at 18 Weeks of Gestation to Predict Preterm Birth in Asymptomatic High-Risk Women

AU - Hezelgrave Elliott, Natasha

AU - Abbott, Danielle S.

AU - Radford, Samara K.

AU - Seed, Paul T.

AU - Girling, Joanna C.

AU - Filmer, Judy

AU - Tribe, Rachel M.

AU - Shennan, Andrew H.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - OBJECTIVE: To compare quantitative fetal fibronectin measurement from 18 to 21 weeks of gestation to measurement at 22-27 weeks of gestation for the prediction of spontaneous preterm birth. METHODS: In a prospective cohort study, we studied the accuracy of cervicovaginal fluid quantitative fetal fibronectin concentrations measured between 18 0/7 weeks of gestation and 21 6/7 weeks of gestation in high-risk asymptomatic women to predict spontaneous preterm birth before 34 weeks of gestation. Predefined fibronectin thresholds were 10 or greater, 50 or greater, and 200 ng/mL or greater. Diagnostic accuracy of the early test (n898) was compared with the standard test performed between 22 0/7 and 27 6/7 weeks of gestation (n691) in the same cohort. Subgroup analysis was performed according to cervical length measurement. RESULTS: Of 898 women, 8.7% delivered spontaneously before 34 weeks of gestation. Only 3.8% of the women with concentrations less than 10 ng/mL (65% of test results) delivered before 34 weeks of gestation. A concentration threshold of 10 ng/mL measured at 18 and 22 weeks of gestation had comparably high sensitivity (early 0.71, 95% confidence interval 0.60-0.81; standard 0.76, 0.63-0.87) and negative predictive value (early 0.96, 0.94-0.98; standard 0.97, 0.95-0.99) for delivery before 34 weeks of gestation. Specificity was also comparable (early 0.69, 0.65-0.72; standard 0.70, 0.66-0.74). A threshold of 200 ng/mL had high specificity (early 0.96, 0.94-0.98; standard 0.96, 0.94-0.97) with lower sensitivity (early 0.26, 0.17-0.37; standard 0.35, 0.22-0.49). Consideration of cervical length strengthened prediction. CONCLUSION: Quantitative cervicovaginal fetal fibronectin measured from 18 to 21 weeks of gestation has similar predictive value as measurement at 22-27 weeks of gestation for prediction of spontaneous preterm birth. Low fibronectin concentrations are associated with spontaneous preterm birthrates approaching population background levels.

AB - OBJECTIVE: To compare quantitative fetal fibronectin measurement from 18 to 21 weeks of gestation to measurement at 22-27 weeks of gestation for the prediction of spontaneous preterm birth. METHODS: In a prospective cohort study, we studied the accuracy of cervicovaginal fluid quantitative fetal fibronectin concentrations measured between 18 0/7 weeks of gestation and 21 6/7 weeks of gestation in high-risk asymptomatic women to predict spontaneous preterm birth before 34 weeks of gestation. Predefined fibronectin thresholds were 10 or greater, 50 or greater, and 200 ng/mL or greater. Diagnostic accuracy of the early test (n898) was compared with the standard test performed between 22 0/7 and 27 6/7 weeks of gestation (n691) in the same cohort. Subgroup analysis was performed according to cervical length measurement. RESULTS: Of 898 women, 8.7% delivered spontaneously before 34 weeks of gestation. Only 3.8% of the women with concentrations less than 10 ng/mL (65% of test results) delivered before 34 weeks of gestation. A concentration threshold of 10 ng/mL measured at 18 and 22 weeks of gestation had comparably high sensitivity (early 0.71, 95% confidence interval 0.60-0.81; standard 0.76, 0.63-0.87) and negative predictive value (early 0.96, 0.94-0.98; standard 0.97, 0.95-0.99) for delivery before 34 weeks of gestation. Specificity was also comparable (early 0.69, 0.65-0.72; standard 0.70, 0.66-0.74). A threshold of 200 ng/mL had high specificity (early 0.96, 0.94-0.98; standard 0.96, 0.94-0.97) with lower sensitivity (early 0.26, 0.17-0.37; standard 0.35, 0.22-0.49). Consideration of cervical length strengthened prediction. CONCLUSION: Quantitative cervicovaginal fetal fibronectin measured from 18 to 21 weeks of gestation has similar predictive value as measurement at 22-27 weeks of gestation for prediction of spontaneous preterm birth. Low fibronectin concentrations are associated with spontaneous preterm birthrates approaching population background levels.

UR - http://www.scopus.com/inward/record.url?scp=84955456105&partnerID=8YFLogxK

U2 - 10.1097/AOG.0000000000001240

DO - 10.1097/AOG.0000000000001240

M3 - Article

AN - SCOPUS:84955456105

VL - 127

SP - 255

EP - 263

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 2

ER -

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