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Quantitative fetal fibronectin to predict preterm birth in women with previous cervical surgery

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Quantitative fetal fibronectin to predict preterm birth in women with previous cervical surgery. / Vandermolen, Brooke I.; Hezelgrave, Natasha L.; Smout, Elizabeth; Abbott, Danielle S.; Seed, Paul T.; Shennan, Andrew H.

In: American Journal of Obstetrics and Gynecology, 04.06.2016.

Research output: Contribution to journalArticle

Harvard

Vandermolen, BI, Hezelgrave, NL, Smout, E, Abbott, DS, Seed, PT & Shennan, AH 2016, 'Quantitative fetal fibronectin to predict preterm birth in women with previous cervical surgery', American Journal of Obstetrics and Gynecology. https://doi.org/10.1016/j.ajog.2016.05.020

APA

Vandermolen, B. I., Hezelgrave, N. L., Smout, E., Abbott, D. S., Seed, P. T., & Shennan, A. H. (2016). Quantitative fetal fibronectin to predict preterm birth in women with previous cervical surgery. American Journal of Obstetrics and Gynecology. https://doi.org/10.1016/j.ajog.2016.05.020

Vancouver

Vandermolen BI, Hezelgrave NL, Smout E, Abbott DS, Seed PT, Shennan AH. Quantitative fetal fibronectin to predict preterm birth in women with previous cervical surgery. American Journal of Obstetrics and Gynecology. 2016 Jun 4. https://doi.org/10.1016/j.ajog.2016.05.020

Author

Vandermolen, Brooke I. ; Hezelgrave, Natasha L. ; Smout, Elizabeth ; Abbott, Danielle S. ; Seed, Paul T. ; Shennan, Andrew H. / Quantitative fetal fibronectin to predict preterm birth in women with previous cervical surgery. In: American Journal of Obstetrics and Gynecology. 2016.

Bibtex Download

@article{bb0fe69a6c104e19a7d586b06bf0446b,
title = "Quantitative fetal fibronectin to predict preterm birth in women with previous cervical surgery",
abstract = "Background:Quantitative fetal fibronectin testing has demonstrated accuracy for prediction of spontaneous preterm birth in asymptomatic women with a prior history of preterm birth. Predictive accuracy in women with previous cervical surgery (a potentially different risk mechanism) is not known. Objective:To compare the predictive accuracy of cervicovaginal fluid quantitative fetal fibronectin and cervical length testing in asymptomatic women with previous cervical surgery to that in women with one previous preterm birth. Study Design A prospective blinded secondary analysis of a larger observational study of cervicovaginal fluid quantitative fetal fibronectin concentration in asymptomatic women measured with a Hologic 10q system (Hologic, Marlborough, MA). Prediction of spontaneous preterm birth (<30, 34 and 37 weeks) with cervicovaginal fluid quantitative fetal fibronectin concentration in primiparous women who had undergone at least one invasive cervical procedure (n=473) was compared with prediction in women who had previous spontaneous preterm birth, preterm prelabour rupture of membranes or late miscarriage (n=821). Relationship with cervical length was explored. Results:The rate of spontaneous preterm birth <34 weeks’ in the cervical surgery group was 3{\%} compared with 9{\%} in previous spontaneous preterm birth group. Receiver operating characteristic curves comparing quantitative fetal fibronectin for prediction at all 3 gestational end-points were comparable between the cervical surgery and previous spontaneous preterm birth groups; (34 weeks: area under the curve 0.78 [0.64-0.93] vs. 0.71 [0.64-0.78] p=0.39). Prediction of spontaneous preterm birth using cervical length compared with quantitative fetal fibronectin for prediction of preterm birth before 34 weeks of gestation offered similar prediction; area under the curve 0.88 [0.79-0.96] vs. 0.77 [0.62-0.92] p=0.12 in the cervical surgery group; 0.77 [0.70-0.84] vs. 0.74 [0.67-0.81] p=0.32 in the previous spontaneous preterm birth group. Conclusion:Prediction of spontaneous preterm birth using cervicovaginal fluid quantitative fetal fibronectin in asymptomatic women with cervical surgery is valid, and has comparative accuracy to that in women with a history of spontaneous preterm birth.",
author = "Vandermolen, {Brooke I.} and Hezelgrave, {Natasha L.} and Elizabeth Smout and Abbott, {Danielle S.} and Seed, {Paul T.} and Shennan, {Andrew H.}",
year = "2016",
month = "6",
day = "4",
doi = "10.1016/j.ajog.2016.05.020",
language = "English",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Quantitative fetal fibronectin to predict preterm birth in women with previous cervical surgery

AU - Vandermolen, Brooke I.

AU - Hezelgrave, Natasha L.

AU - Smout, Elizabeth

AU - Abbott, Danielle S.

AU - Seed, Paul T.

AU - Shennan, Andrew H.

PY - 2016/6/4

Y1 - 2016/6/4

N2 - Background:Quantitative fetal fibronectin testing has demonstrated accuracy for prediction of spontaneous preterm birth in asymptomatic women with a prior history of preterm birth. Predictive accuracy in women with previous cervical surgery (a potentially different risk mechanism) is not known. Objective:To compare the predictive accuracy of cervicovaginal fluid quantitative fetal fibronectin and cervical length testing in asymptomatic women with previous cervical surgery to that in women with one previous preterm birth. Study Design A prospective blinded secondary analysis of a larger observational study of cervicovaginal fluid quantitative fetal fibronectin concentration in asymptomatic women measured with a Hologic 10q system (Hologic, Marlborough, MA). Prediction of spontaneous preterm birth (<30, 34 and 37 weeks) with cervicovaginal fluid quantitative fetal fibronectin concentration in primiparous women who had undergone at least one invasive cervical procedure (n=473) was compared with prediction in women who had previous spontaneous preterm birth, preterm prelabour rupture of membranes or late miscarriage (n=821). Relationship with cervical length was explored. Results:The rate of spontaneous preterm birth <34 weeks’ in the cervical surgery group was 3% compared with 9% in previous spontaneous preterm birth group. Receiver operating characteristic curves comparing quantitative fetal fibronectin for prediction at all 3 gestational end-points were comparable between the cervical surgery and previous spontaneous preterm birth groups; (34 weeks: area under the curve 0.78 [0.64-0.93] vs. 0.71 [0.64-0.78] p=0.39). Prediction of spontaneous preterm birth using cervical length compared with quantitative fetal fibronectin for prediction of preterm birth before 34 weeks of gestation offered similar prediction; area under the curve 0.88 [0.79-0.96] vs. 0.77 [0.62-0.92] p=0.12 in the cervical surgery group; 0.77 [0.70-0.84] vs. 0.74 [0.67-0.81] p=0.32 in the previous spontaneous preterm birth group. Conclusion:Prediction of spontaneous preterm birth using cervicovaginal fluid quantitative fetal fibronectin in asymptomatic women with cervical surgery is valid, and has comparative accuracy to that in women with a history of spontaneous preterm birth.

AB - Background:Quantitative fetal fibronectin testing has demonstrated accuracy for prediction of spontaneous preterm birth in asymptomatic women with a prior history of preterm birth. Predictive accuracy in women with previous cervical surgery (a potentially different risk mechanism) is not known. Objective:To compare the predictive accuracy of cervicovaginal fluid quantitative fetal fibronectin and cervical length testing in asymptomatic women with previous cervical surgery to that in women with one previous preterm birth. Study Design A prospective blinded secondary analysis of a larger observational study of cervicovaginal fluid quantitative fetal fibronectin concentration in asymptomatic women measured with a Hologic 10q system (Hologic, Marlborough, MA). Prediction of spontaneous preterm birth (<30, 34 and 37 weeks) with cervicovaginal fluid quantitative fetal fibronectin concentration in primiparous women who had undergone at least one invasive cervical procedure (n=473) was compared with prediction in women who had previous spontaneous preterm birth, preterm prelabour rupture of membranes or late miscarriage (n=821). Relationship with cervical length was explored. Results:The rate of spontaneous preterm birth <34 weeks’ in the cervical surgery group was 3% compared with 9% in previous spontaneous preterm birth group. Receiver operating characteristic curves comparing quantitative fetal fibronectin for prediction at all 3 gestational end-points were comparable between the cervical surgery and previous spontaneous preterm birth groups; (34 weeks: area under the curve 0.78 [0.64-0.93] vs. 0.71 [0.64-0.78] p=0.39). Prediction of spontaneous preterm birth using cervical length compared with quantitative fetal fibronectin for prediction of preterm birth before 34 weeks of gestation offered similar prediction; area under the curve 0.88 [0.79-0.96] vs. 0.77 [0.62-0.92] p=0.12 in the cervical surgery group; 0.77 [0.70-0.84] vs. 0.74 [0.67-0.81] p=0.32 in the previous spontaneous preterm birth group. Conclusion:Prediction of spontaneous preterm birth using cervicovaginal fluid quantitative fetal fibronectin in asymptomatic women with cervical surgery is valid, and has comparative accuracy to that in women with a history of spontaneous preterm birth.

U2 - 10.1016/j.ajog.2016.05.020

DO - 10.1016/j.ajog.2016.05.020

M3 - Article

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

ER -

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