Quantitative Swept-Source Optical Coherence Tomography of Early Enamel Erosion in vivo

TY - JOUR

T1 - Quantitative Swept-Source Optical Coherence Tomography of Early Enamel Erosion in vivo

AU - Austin, R.S.

AU - Haji Taha, Zaitun

AU - Festy, F.

AU - Cook, R.

AU - Andiappan, M.

AU - J., Gomez

AU - I.A., Pretty

AU - Moazzez, Rebecca

PY - 2017/8/31

Y1 - 2017/8/31

N2 - Swept-source optical coherence tomography (SS-OCT) has potential for in vivo quantitative evaluation of micro-structural enamel surface phenomena occurring during early erosive demineralisation. This randomized controlled single-blind crossover clinical study aimed to evaluate the use of SS-OCT for detection of optical changes in the enamel of 30 healthy volunteers subjected to orange juice rinsing (erosive challenge) in comparison to mineral water rinsing (control), according to wiped and non-wiped enamel surface states. Participants were randomly allocated to 60 minutes orange juice rinsing (pH 3.8) followed by 60 minutes water rinsing (pH 6.7) and vice versa, with a two-week wash-out period. In addition, the labial surfaces of the right or left maxillary incisors were wiped prior to SS-OCT imaging. An automated ImageJ algorithm was designed to analyse the backscattered OCT signal intensity (D) after orange juice rinsing compared to after water rinsing. D was quantified as the OCT signal scattering from the ~33 µm subsurface enamel, normalised by the total OCT signal intensity entering the enamel. The backscattered OCT signal intensity increased 3.1% (95% CI 1.1% to 5.1%) in the wiped incisors and 3.5% (95% CI 1.5% to 5.5%) in the unwiped incisors (P<0.0001). Wiping reduced the backscattered OCT signal intensity by 1.7% (95% CI -3.2 % to -0.3%) (p=0.02), in comparison to the unwiped enamel surfaces, for both rinsing solutions (P=0.2). Swept-source Optical Coherence Tomography detected OCT signal changes in the superficial subsurface enamel of maxillary central incisor teeth of healthy volunteers after orange juice rinsing.

AB - Swept-source optical coherence tomography (SS-OCT) has potential for in vivo quantitative evaluation of micro-structural enamel surface phenomena occurring during early erosive demineralisation. This randomized controlled single-blind crossover clinical study aimed to evaluate the use of SS-OCT for detection of optical changes in the enamel of 30 healthy volunteers subjected to orange juice rinsing (erosive challenge) in comparison to mineral water rinsing (control), according to wiped and non-wiped enamel surface states. Participants were randomly allocated to 60 minutes orange juice rinsing (pH 3.8) followed by 60 minutes water rinsing (pH 6.7) and vice versa, with a two-week wash-out period. In addition, the labial surfaces of the right or left maxillary incisors were wiped prior to SS-OCT imaging. An automated ImageJ algorithm was designed to analyse the backscattered OCT signal intensity (D) after orange juice rinsing compared to after water rinsing. D was quantified as the OCT signal scattering from the ~33 µm subsurface enamel, normalised by the total OCT signal intensity entering the enamel. The backscattered OCT signal intensity increased 3.1% (95% CI 1.1% to 5.1%) in the wiped incisors and 3.5% (95% CI 1.5% to 5.5%) in the unwiped incisors (P<0.0001). Wiping reduced the backscattered OCT signal intensity by 1.7% (95% CI -3.2 % to -0.3%) (p=0.02), in comparison to the unwiped enamel surfaces, for both rinsing solutions (P=0.2). Swept-source Optical Coherence Tomography detected OCT signal changes in the superficial subsurface enamel of maxillary central incisor teeth of healthy volunteers after orange juice rinsing.

U2 - 10.1159/000477098

DO - 10.1159/000477098

M3 - Article

SN - 0008-6568

VL - 51

SP - 410

EP - 418

JO - Caries research

JF - Caries research

IS - 4

ER -