Quantitative techniques in (18)FDG PET scanning in oncology

TY - JOUR

T1 - Quantitative techniques in (18)FDG PET scanning in oncology

AU - Castell, F.

AU - Cook, G. J. R.

N1 - M1 - 10 Times Cited: 20

PY - 2008/5/20

Y1 - 2008/5/20

N2 - The clinical applications of (18)F-fluoro-2-deoxyglucose ((18)FDG) positron emission tomography (PET) in oncology are becoming established. While simple static scanning techniques are used for the majority of routine clinical examinations, increasing use of PET in clinical trials to monitor treatment response with (18)FDG and novel tracers reflecting different pharmacodynamic end points, often necessitates a more complex and quantitative analysis of radiopharmaceutical kinetics. A wide range of PET analysis techniques exist, ranging from simple visual analysis and semiquantitative methods to full dynamic studies with kinetic analysis. These methods are discussed, focusing particularly on the available methodologies that can be utilised in clinical trials.

AB - The clinical applications of (18)F-fluoro-2-deoxyglucose ((18)FDG) positron emission tomography (PET) in oncology are becoming established. While simple static scanning techniques are used for the majority of routine clinical examinations, increasing use of PET in clinical trials to monitor treatment response with (18)FDG and novel tracers reflecting different pharmacodynamic end points, often necessitates a more complex and quantitative analysis of radiopharmaceutical kinetics. A wide range of PET analysis techniques exist, ranging from simple visual analysis and semiquantitative methods to full dynamic studies with kinetic analysis. These methods are discussed, focusing particularly on the available methodologies that can be utilised in clinical trials.

U2 - 10.1038/sj.bjc.6604330

DO - 10.1038/sj.bjc.6604330

M3 - Article

SN - 0007-0920

VL - 98

SP - 1597

EP - 1601

JO - BJC: British Journal of Cancer

JF - BJC: British Journal of Cancer

IS - 10

ER -