Radiosynthesis of [I-123]N-(3-iodoprop-(2E)-enyl)-2 alpha-(imino-methyl)-3 beta-(3 ',4 '-dichlorophenyl) nortropane as a potential SPET tracer for dopamine transporter

TY - JOUR

T1 - Radiosynthesis of [I-123]N-(3-iodoprop-(2E)-enyl)-2 alpha-(imino-methyl)-3 beta-(3 ',4 '-dichlorophenyl) nortropane as a potential SPET tracer for dopamine transporter

AU - Yu, M X

AU - Airaksinen, A J

AU - Gee, A D

AU - Lotjonen, S

AU - Kuikka, J T

AU - Vepsalainen, J J

AU - Hiltunen, J

AU - Bergstrom, K A

PY - 2002/10/30

Y1 - 2002/10/30

N2 - The radiosynthesis of a novel tropane derivative [I-123]KUC-25019, [[I-123] N-(3-iodoprop-(2E)-enyl)-2alpha-(imino-methyl)-3beta-(3',4'-dichlorophenyl)nortropane], a potential inhibitor of the dopamine transporter is reported. The synthetic routes include the preparation of standard reference, the stannyl precursor and the I-123-labeling synthesis. The no-carrier-added I-123-labeling has about 20% yield, the specific activity of [I-123]KUC-25019 is > 107 GBq/ mumol and the radiochemical purity of [I-123] KUC-25019 is >95%. Copyright (C) 2002 John Wiley Sons, Ltd.

AB - The radiosynthesis of a novel tropane derivative [I-123]KUC-25019, [[I-123] N-(3-iodoprop-(2E)-enyl)-2alpha-(imino-methyl)-3beta-(3',4'-dichlorophenyl)nortropane], a potential inhibitor of the dopamine transporter is reported. The synthetic routes include the preparation of standard reference, the stannyl precursor and the I-123-labeling synthesis. The no-carrier-added I-123-labeling has about 20% yield, the specific activity of [I-123]KUC-25019 is > 107 GBq/ mumol and the radiochemical purity of [I-123] KUC-25019 is >95%. Copyright (C) 2002 John Wiley Sons, Ltd.

U2 - 10.1002/jlcr.619

DO - 10.1002/jlcr.619

M3 - Article

SN - 0362-4803

VL - 45

SP - 1011

EP - 1017

JO - JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

JF - JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

IS - 12

ER -