TY - JOUR
T1 - Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds
AU - Shegani, Antonio
AU - Kealey, Steven
AU - Luzi, Federico
AU - Basagni, Filippo
AU - MacHado, Joana Do Mar
AU - Dogan Ekici, Sevban
AU - Ferocino, Alessandra
AU - Gee, Tony
AU - Bongarzone, Salvatore
N1 - Funding Information:
This work was supported by core funding from the Wellcome/EPSRC Centre for Medical Engineering [WT203148/Z/16/Z], EPSRC programme for Next Generation Molecular Imaging and Therapy with Radionuclides (EP/S032789/1, “MITHRAS”), Antonio Shegani gratefully acknowledges the Bodossaki Foundation, Stamatis G. Mantzavinos’s Memorial Postdoctoral Scholarship and GlaxoSmithKline (GSK) [3000034923] for the financial support. We thank Dr. Abdul Karim Haji Dheere, Dr. Mitja Kovac, Layla Alsulaimani and Dr. Thomas Bonasera for their expertise and assistance throughout all aspects of our review.
Publisher Copyright:
© 2022 The Authors. Published by American Chemical Society.
PY - 2022/11/18
Y1 - 2022/11/18
N2 - The presence of positron emission tomography (PET) centers at most major hospitals worldwide, along with the improvement of PET scanner sensitivity and the introduction of total body PET systems, has increased the interest in the PET tracer development using the short-lived radionuclides carbon-11. In the last few decades, methodological improvements and fully automated modules have allowed the development of carbon-11 tracers for clinical use. Radiolabeling natural compounds with carbon-11 by substituting one of the backbone carbons with the radionuclide has provided important information on the biochemistry of the authentic compounds and increased the understanding of their in vivo behavior in healthy and diseased states. The number of endogenous and natural compounds essential for human life is staggering, ranging from simple alcohols to vitamins and peptides. This review collates all the carbon-11 radiolabeled endogenous and natural exogenous compounds synthesised to date, including essential information on their radiochemistry methodologies and preclinical and clinical studies in healthy subjects.
AB - The presence of positron emission tomography (PET) centers at most major hospitals worldwide, along with the improvement of PET scanner sensitivity and the introduction of total body PET systems, has increased the interest in the PET tracer development using the short-lived radionuclides carbon-11. In the last few decades, methodological improvements and fully automated modules have allowed the development of carbon-11 tracers for clinical use. Radiolabeling natural compounds with carbon-11 by substituting one of the backbone carbons with the radionuclide has provided important information on the biochemistry of the authentic compounds and increased the understanding of their in vivo behavior in healthy and diseased states. The number of endogenous and natural compounds essential for human life is staggering, ranging from simple alcohols to vitamins and peptides. This review collates all the carbon-11 radiolabeled endogenous and natural exogenous compounds synthesised to date, including essential information on their radiochemistry methodologies and preclinical and clinical studies in healthy subjects.
UR - http://www.scopus.com/inward/record.url?scp=85142632773&partnerID=8YFLogxK
U2 - 10.1021/acs.chemrev.2c00398
DO - 10.1021/acs.chemrev.2c00398
M3 - Article
AN - SCOPUS:85142632773
SN - 0009-2665
JO - Chemical Reviews
JF - Chemical Reviews
ER -