Abstract
Some aspects of vascular reactivity are altered in mild experimental uraemia, as shown by increased myogenic tone and a reduced lumen diameter in the femoral artery. This study was conducted to investigate the prevention of these uraemia-induced vascular abnormalities by the angiotensin-converting enzyme inhibitor (ACE-I) Ramipril. Ten male Wistar rats were rendered uraemic (U) by 5/6th nephrectomy, and 10 control (C) rats were concurrently sham-operated. After 4 weeks, both groups were given daily subcutaneous injections of 3 microg of Ramipril for a further 4 weeks. Tail-cuff systolic blood pressure was then recorded and the rat was killed. Isolated femoral arteries were mounted on a pressure myograph and pressurized at 40 mmHg for baseline measurements of the lumen internal diameter. Myogenic tone was then assessed over a range of intravascular pressures from 40 to 160 mmHg. Biochemically, serum urea and creatinine were significantly higher in the uraemic (U) group [urea: U, 23+/-3 mmol/l; C, 6+/-1 mmol/l (P
Original language | English |
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Pages (from-to) | 233-7 |
Number of pages | 5 |
Journal | Clinical Science |
Volume | 97 |
Issue number | 2 |
Publication status | Published - Aug 1999 |
Keywords
- Angiotensin-Converting Enzyme Inhibitors
- Animals
- Femoral Artery
- Male
- Muscle Tonus
- Muscle, Smooth, Vascular
- Myography
- Ramipril
- Rats
- Rats, Wistar
- Uremia
- Vasoconstriction