Ramipril prevents basal arterial constriction and enhanced myogenic tone in the femoral artery in mildly uraemic normotensive rats

T Savage, A C McMahon, A Mullen, R M Tribe, M M Yaqoob

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6 Citations (Scopus)

Abstract

Some aspects of vascular reactivity are altered in mild experimental uraemia, as shown by increased myogenic tone and a reduced lumen diameter in the femoral artery. This study was conducted to investigate the prevention of these uraemia-induced vascular abnormalities by the angiotensin-converting enzyme inhibitor (ACE-I) Ramipril. Ten male Wistar rats were rendered uraemic (U) by 5/6th nephrectomy, and 10 control (C) rats were concurrently sham-operated. After 4 weeks, both groups were given daily subcutaneous injections of 3 microg of Ramipril for a further 4 weeks. Tail-cuff systolic blood pressure was then recorded and the rat was killed. Isolated femoral arteries were mounted on a pressure myograph and pressurized at 40 mmHg for baseline measurements of the lumen internal diameter. Myogenic tone was then assessed over a range of intravascular pressures from 40 to 160 mmHg. Biochemically, serum urea and creatinine were significantly higher in the uraemic (U) group [urea: U, 23+/-3 mmol/l; C, 6+/-1 mmol/l (P
Original languageEnglish
Pages (from-to)233-7
Number of pages5
JournalClinical Science
Volume97
Issue number2
Publication statusPublished - Aug 1999

Keywords

  • Angiotensin-Converting Enzyme Inhibitors
  • Animals
  • Femoral Artery
  • Male
  • Muscle Tonus
  • Muscle, Smooth, Vascular
  • Myography
  • Ramipril
  • Rats
  • Rats, Wistar
  • Uremia
  • Vasoconstriction

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