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Random Style Transfer Based Domain Generalization Networks Integrating Shape and Spatial Information

Research output: Chapter in Book/Report/Conference proceedingConference paperpeer-review

Lei Li, Veronika A. Zimmer, Wangbin Ding, Fuping Wu, Liqin Huang, Julia A. Schnabel, Xiahai Zhuang

Original languageEnglish
Title of host publicationStatistical Atlases and Computational Models of the Heart. MandMs and EMIDEC Challenges - 11th International Workshop, STACOM 2020, Held in Conjunction with MICCAI 2020, Revised Selected Papers
EditorsEsther Puyol Anton, Mihaela Pop, Maxime Sermesant, Victor Campello, Alain Lalande, Karim Lekadir, Avan Suinesiaputra, Oscar Camara, Alistair Young
PublisherSpringer Science and Business Media Deutschland GmbH
Number of pages11
ISBN (Print)9783030681067
Event11th International Workshop on Statistical Atlases and Computational Models of the Heart, STACOM 2020 held in Conjunction with MICCAI 2020 - Lima, Peru
Duration: 4 Oct 20204 Oct 2020

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume12592 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Conference11th International Workshop on Statistical Atlases and Computational Models of the Heart, STACOM 2020 held in Conjunction with MICCAI 2020

Bibliographical note

Funding Information: This work was supported by the National Natural Science Foundation of China (61971142), and L. Li was partially supported by the CSC Scholarship. JA Schnabel and VA Zimmer would like to acknowledge funding from a Wellcome Trust IEH Award (WT 102431), an EPSRC program Grant (EP/P001009/1), and the Wellcome/EPSRC Center for Medical Engineering (WT 203148/Z/16/Z). Publisher Copyright: © 2021, Springer Nature Switzerland AG. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

King's Authors


Deep learning (DL)-based models have demonstrated good performance in medical image segmentation. However, the models trained on a known dataset often fail when performed on an unseen dataset collected from different centers, vendors and disease populations. In this work, we present a random style transfer network to tackle the domain generalization problem for multi-vendor and center cardiac image segmentation. Style transfer is used to generate training data with a wider distribution/heterogeneity, namely domain augmentation. As the target domain could be unknown, we randomly generate a modality vector for the target modality in the style transfer stage, to simulate the domain shift for unknown domains. The model can be trained in a semi-supervised manner by simultaneously optimizing a supervised segmentation and a unsupervised style translation objective. Besides, the framework incorporates the spatial information and shape prior of the target by introducing two regularization terms. We evaluated the proposed framework on 40 subjects from the M&Ms challenge2020, and obtained promising performance in the segmentation for data from unknown vendors and centers.

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