Rapid and efficient synthesis of [11C]ureas via the incorporation of [11C]CO2 into aliphatic and aromatic amines

TY - JOUR

T1 - Rapid and efficient synthesis of [11C]ureas via the incorporation of [11C]CO2 into aliphatic and aromatic amines

AU - Haji Dheere, Abdul Karim

AU - Yusuf, Nadiya

AU - Gee, Antony

PY - 2013/9/25

Y1 - 2013/9/25

N2 - A rapid urea radiolabelling methodology has been developed. [(11)C]CO2 was activated by 1,8-diazabicycloundec-7-ene (DBU) in the presence of aliphatic and aromatic amines and reacted with Mitsunobu reagents to produce asymmetric (11)C radiolabelled ureas in high radiochemical yields.

AB - A rapid urea radiolabelling methodology has been developed. [(11)C]CO2 was activated by 1,8-diazabicycloundec-7-ene (DBU) in the presence of aliphatic and aromatic amines and reacted with Mitsunobu reagents to produce asymmetric (11)C radiolabelled ureas in high radiochemical yields.

U2 - 10.1039/c3cc44046j

DO - 10.1039/c3cc44046j

M3 - Article

C2 - 23925577

SN - 1364-548X

VL - 49

SP - 8193

EP - 8195

JO - Chemical communications (Cambridge, England)

JF - Chemical communications (Cambridge, England)

IS - 74

M1 - N/A

ER -