Rapid and efficient synthesis of [11C]ureas via the incorporation of [11C]CO2 into aliphatic and aromatic amines

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Abstract

A rapid urea radiolabelling methodology has been developed. [(11)C]CO2 was activated by 1,8-diazabicycloundec-7-ene (DBU) in the presence of aliphatic and aromatic amines and reacted with Mitsunobu reagents to produce asymmetric (11)C radiolabelled ureas in high radiochemical yields.
Original languageEnglish
Article numberN/A
Pages (from-to)8193-8195
Number of pages3
JournalChemical communications (Cambridge, England)
Volume49
Issue number74
Early online date31 Jul 2013
DOIs
Publication statusPublished - 25 Sept 2013

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