TY - JOUR
T1 - Rapid homeostatic turnover of embryonic ECM during tissue morphogenesis
AU - Matsubayashi, Yutaka
AU - Sánchez Sánchez, Besaiz
AU - Marcotti, Stefania
AU - Serna Morales, Eduardo
AU - Dragu, Anca
AU - Díaz-de-la-Loza, María-del-Carmen
AU - Vizcay-Barrena, Gema
AU - Fleck, Roland
AU - Stramer, Brian
PY - 2020/7/6
Y1 - 2020/7/6
N2 - The extracellular matrix (ECM) is hypothesized to form a long-lived cellular scaffold. Using modeling and in vivo pulse-chase experiments, Matsubayashi, Sánchez-Sánchez et al. show that the embryonic fruit fly ECM has a surprisingly short half-life. This labile ECM network is likely necessary to maintain plasticity for growth and morphogenesis.
AB - The extracellular matrix (ECM) is hypothesized to form a long-lived cellular scaffold. Using modeling and in vivo pulse-chase experiments, Matsubayashi, Sánchez-Sánchez et al. show that the embryonic fruit fly ECM has a surprisingly short half-life. This labile ECM network is likely necessary to maintain plasticity for growth and morphogenesis.
KW - Collagen
KW - Matrix metalloprotease
KW - Nidogen
KW - Perlecan
KW - basement membrane
KW - embryogenesis
KW - extracellular matrix
KW - mathematical modeling
KW - morphogenesis
KW - turnover
UR - http://www.scopus.com/inward/record.url?scp=85086930604&partnerID=8YFLogxK
U2 - 10.1016/j.devcel.2020.06.005
DO - 10.1016/j.devcel.2020.06.005
M3 - Article
SN - 1534-5807
VL - 54
SP - 33-42.e9
JO - Developmental Cell
JF - Developmental Cell
IS - 1
ER -