Rapid homeostatic turnover of embryonic ECM during tissue morphogenesis

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Abstract

The extracellular matrix (ECM) is hypothesized to form a long-lived cellular scaffold. Using modeling and in vivo pulse-chase experiments, Matsubayashi, Sánchez-Sánchez et al. show that the embryonic fruit fly ECM has a surprisingly short half-life. This labile ECM network is likely necessary to maintain plasticity for growth and morphogenesis.

Original languageEnglish
Pages (from-to)33-42.e9
JournalDevelopmental Cell
Volume54
Issue number1
Early online date24 Jun 2020
DOIs
Publication statusPublished - 6 Jul 2020

Keywords

  • Collagen
  • Matrix metalloprotease
  • Nidogen
  • Perlecan
  • basement membrane
  • embryogenesis
  • extracellular matrix
  • mathematical modeling
  • morphogenesis
  • turnover

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