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Rapid homeostatic turnover of embryonic ECM during tissue morphogenesis

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)33-42.e9
JournalDevelopmental Cell
Volume54
Issue number1
Early online date24 Jun 2020
DOIs
Accepted/In press2 Jun 2020
E-pub ahead of print24 Jun 2020
Published6 Jul 2020

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King's Authors

Abstract

The extracellular matrix (ECM) is hypothesized to form a long-lived cellular scaffold. Using modeling and in vivo pulse-chase experiments, Matsubayashi, Sánchez-Sánchez et al. show that the embryonic fruit fly ECM has a surprisingly short half-life. This labile ECM network is likely necessary to maintain plasticity for growth and morphogenesis.

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