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Rapid neonatal weight gain in rats results in a renal ubiquinone (CoQ) deficiency associated with premature death

Research output: Contribution to journalArticlepeer-review

P Shelley, J Tarry-Adkins, M Martin-Gronert, L Poston, S Heales, J Clark, S Ozanne, J McConnell

Original languageEnglish
Pages (from-to)681 - 687
Number of pages7
JournalMechanisms of Ageing and Development
Volume128
Issue number11-12
DOIs
PublishedNov 2007

King's Authors

Abstract

We have recently reported that maternal dietary imbalance during pregnancy and lactation can reduce the lifespan of offspring. Rats that were growth restricted in utero by maternal protein restriction and underwent rapid weight gain when suckled by control fed dams died earlier than animals whose mothers were fed a control diet throughout pregnancy and lactation. We demonstrate here that mitochondrial abnormalities and DNA damage occur in the kidney of offspring who die prematurely. We have established by direct measurement and by in vitro supplementation that mitochondrial abnormalities occur because of a functional deficit of the mitochondrial cofactor coenzyme Q9 (CoQ9). These data provide molecular insight into the association between maternal nutrition and determination of offspring lifespan, and identify, a potential dietary intervention to prevent detrimental consequences of imbalanced maternal nutrition. (c) 2007 Elsevier Ireland Ltd. All rights reserved

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