Abstract
We have measured the effect of rat odorant-binding protein 1 on the rates of ligand uptake and liquid-to-air transfer rates with a set of defined odorous compounds. Comparison of observed rate constants (k(obs)) with data simulated over a wide range of different kinetic and thermodynamic regimes shows that the data do not agree with the previously held view of a slow off-rate regime (k(off) <0.0004 s(-1)). We propose that a rapid k(off) would be a necessary requirement for such a system, since slow odorant-release rates would result in significant decorrelation between the olfactory world and odour perception.
| Original language | English |
|---|---|
| Pages (from-to) | 372-80 |
| Number of pages | 9 |
| Journal | Journal of Molecular Biology |
| Volume | 404 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 3 Dec 2010 |
Keywords
- Acetates
- Animals
- Calorimetry
- In Vitro Techniques
- Kinetics
- Ligands
- Mass Spectrometry
- Odors
- Rats
- Receptors, Odorant
- Recombinant Proteins
- Signal Transduction
- Smell
- Thermodynamics
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