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Rare variants in Fanconi anemia genes are enriched in acute myeloid leukemia

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Kyaw Ze Ya Maung, Paul J. Leo, Mahmoud Bassal, Debora A. Casolari, James X. Gray, Sarah C. Bray, Stephen Pederson, Deepak Singhal, Saumya E. Samaraweera, Tran Nguyen, Gökhan Cildir, Mhairi Marshall, Adam Ewing, Emma L. Duncan, Matthew A. Brown, Russell Saal, Vinay Tergaonkar, Luen Bik To, Paula Marlton, Devinder Gill & 5 more Ian Lewis, Andrew J. Deans, Anna L. Brown, Richard J. D'Andrea, Thomas J. Gonda

Original languageEnglish
Article number50
JournalBlood Cancer Journal
Volume8
Issue number6
DOIs
Published1 Jun 2018

Bibliographical note

Funding Information: We would like to acknowledge the Leukemia Foundation of Australia for their support of the Australian Leukemia and Lymphoma Group (ALLG) tissue bank. The South Australian Cancer Research Biobank (SACRB) is supported by the Cancer Council SA Beat Cancer Project, Medvet Laboratories Pty Ltd and the Government of South Australia. We would also like to acknowledge the assistance from the Detmold Family Cytometry Facility, Hanson Institute, SA Pathology. The authors thank Brooke Gardiner and colleagues at UQ Centre for Clinical Genomics (UQ Diamantina Institute) for carrying out exome capture and sequencing. We also thank Megan Ellis (ALLG tissue bank) and Carolyn Butcher (SACRB) for invaluable assistance in identifying and preparing samples, Diana Iarossi, Michelle Perugini, Silke Danner and Sarah Moore for assistance with molecular and clinical annotation of AML samples, Crystal McGirr for general technical assistance and Charlotte Hodson for help with analysis of mutation effect on function. We would like to gratefully acknowledge the funding support from the Queen Elizabeth Hospital Hematology-Oncology Private Practice Fund; the Queensland Health Study, Educational and Research Trust Fund; the Royal Adelaide Hospital Contributing Hematologists’ Fund, and the National Health and Medical Research Council (Australia). K.Z.Y.M. is supported by a Queen Elizabeth Hospital Hematology-Oncology Research Award, J.X.G. was supported by a Fellowship from the Princess Alexandra Hospital and Queensland Health, and A.J.D. is supported by the Victorian Cancer Agency fellowship. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

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