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Rasgrf2 controls dopaminergic adaptations to alcohol in mice

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Rasgrf2 controls dopaminergic adaptations to alcohol in mice. / Easton, Alanna C; Rotter, Andrea; Lourdusamy, Anbarasu; Desrivières, Sylvane; Fernández-Medarde, Alberto; Biermann, Teresa; Fernandes, Cathy; Santos, Eugenio; Kornhuber, Johannes; Schumann, Gunter; Müller, Christian P.

In: Brain Research Bulletin, Vol. 109, 22.10.2014, p. 143-150.

Research output: Contribution to journalArticle

Harvard

Easton, AC, Rotter, A, Lourdusamy, A, Desrivières, S, Fernández-Medarde, A, Biermann, T, Fernandes, C, Santos, E, Kornhuber, J, Schumann, G & Müller, CP 2014, 'Rasgrf2 controls dopaminergic adaptations to alcohol in mice', Brain Research Bulletin, vol. 109, pp. 143-150. https://doi.org/10.1016/j.brainresbull.2014.10.008

APA

Easton, A. C., Rotter, A., Lourdusamy, A., Desrivières, S., Fernández-Medarde, A., Biermann, T., Fernandes, C., Santos, E., Kornhuber, J., Schumann, G., & Müller, C. P. (2014). Rasgrf2 controls dopaminergic adaptations to alcohol in mice. Brain Research Bulletin, 109, 143-150. https://doi.org/10.1016/j.brainresbull.2014.10.008

Vancouver

Easton AC, Rotter A, Lourdusamy A, Desrivières S, Fernández-Medarde A, Biermann T et al. Rasgrf2 controls dopaminergic adaptations to alcohol in mice. Brain Research Bulletin. 2014 Oct 22;109:143-150. https://doi.org/10.1016/j.brainresbull.2014.10.008

Author

Easton, Alanna C ; Rotter, Andrea ; Lourdusamy, Anbarasu ; Desrivières, Sylvane ; Fernández-Medarde, Alberto ; Biermann, Teresa ; Fernandes, Cathy ; Santos, Eugenio ; Kornhuber, Johannes ; Schumann, Gunter ; Müller, Christian P. / Rasgrf2 controls dopaminergic adaptations to alcohol in mice. In: Brain Research Bulletin. 2014 ; Vol. 109. pp. 143-150.

Bibtex Download

@article{0c14b18762524ee28ad4062a7f76ab7e,
title = "Rasgrf2 controls dopaminergic adaptations to alcohol in mice",
abstract = "Alcohol abuse leads to serious health problems with no effective treatment available. Recent evidence suggests a role for ras-specific guanine-nucleotide releasing factor 2 (RASGRF2) in alcoholism. Rasgrf2 is a calcium sensor and MAPK/ERK activating protein, which has been linked to neurotransmitter release and monoaminergic receptor adaptations. Rasgrf2 knock out (KO) mice do not develop a dopamine response in the nucleus accumbens after an alcohol challenge and show a reduced consumption of alcohol. The present study aims to further characterise the role of Rasgrf2 in dopaminergic activation beyond the nucleus accumbens following alcohol treatment. Using in vivo microdialysis we found that alcohol induces alterations in dopamine levels in the dorsal striatum between wildtype (WT) and Rasgrf2 KO mice. There was no difference in the expression of dopamine transporter (DAT), dopamine receptor regulating factor (DRRF), or dopamine D2 receptor (DRD2) mRNA in the brain between Rasgrf2 KO and WT mice. After sub-chronic alcohol treatment, DAT and DRRF, but not DRD2 mRNA expression differed between WT and Rasgrf2 KO mice. Brain adaptations were positively correlated with splenic expression levels. These data suggest that Rasgrf2 controls dopaminergic signalling and adaptations to alcohol also in other brain regions, beyond the nucleus accumbens.",
author = "Easton, {Alanna C} and Andrea Rotter and Anbarasu Lourdusamy and Sylvane Desrivi{\`e}res and Alberto Fern{\'a}ndez-Medarde and Teresa Biermann and Cathy Fernandes and Eugenio Santos and Johannes Kornhuber and Gunter Schumann and M{\"u}ller, {Christian P}",
year = "2014",
month = oct,
day = "22",
doi = "10.1016/j.brainresbull.2014.10.008",
language = "English",
volume = "109",
pages = "143--150",
journal = "Brain Research Bulletin",
issn = "0361-9230",
publisher = "Elsevier B.V.",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Rasgrf2 controls dopaminergic adaptations to alcohol in mice

AU - Easton, Alanna C

AU - Rotter, Andrea

AU - Lourdusamy, Anbarasu

AU - Desrivières, Sylvane

AU - Fernández-Medarde, Alberto

AU - Biermann, Teresa

AU - Fernandes, Cathy

AU - Santos, Eugenio

AU - Kornhuber, Johannes

AU - Schumann, Gunter

AU - Müller, Christian P

PY - 2014/10/22

Y1 - 2014/10/22

N2 - Alcohol abuse leads to serious health problems with no effective treatment available. Recent evidence suggests a role for ras-specific guanine-nucleotide releasing factor 2 (RASGRF2) in alcoholism. Rasgrf2 is a calcium sensor and MAPK/ERK activating protein, which has been linked to neurotransmitter release and monoaminergic receptor adaptations. Rasgrf2 knock out (KO) mice do not develop a dopamine response in the nucleus accumbens after an alcohol challenge and show a reduced consumption of alcohol. The present study aims to further characterise the role of Rasgrf2 in dopaminergic activation beyond the nucleus accumbens following alcohol treatment. Using in vivo microdialysis we found that alcohol induces alterations in dopamine levels in the dorsal striatum between wildtype (WT) and Rasgrf2 KO mice. There was no difference in the expression of dopamine transporter (DAT), dopamine receptor regulating factor (DRRF), or dopamine D2 receptor (DRD2) mRNA in the brain between Rasgrf2 KO and WT mice. After sub-chronic alcohol treatment, DAT and DRRF, but not DRD2 mRNA expression differed between WT and Rasgrf2 KO mice. Brain adaptations were positively correlated with splenic expression levels. These data suggest that Rasgrf2 controls dopaminergic signalling and adaptations to alcohol also in other brain regions, beyond the nucleus accumbens.

AB - Alcohol abuse leads to serious health problems with no effective treatment available. Recent evidence suggests a role for ras-specific guanine-nucleotide releasing factor 2 (RASGRF2) in alcoholism. Rasgrf2 is a calcium sensor and MAPK/ERK activating protein, which has been linked to neurotransmitter release and monoaminergic receptor adaptations. Rasgrf2 knock out (KO) mice do not develop a dopamine response in the nucleus accumbens after an alcohol challenge and show a reduced consumption of alcohol. The present study aims to further characterise the role of Rasgrf2 in dopaminergic activation beyond the nucleus accumbens following alcohol treatment. Using in vivo microdialysis we found that alcohol induces alterations in dopamine levels in the dorsal striatum between wildtype (WT) and Rasgrf2 KO mice. There was no difference in the expression of dopamine transporter (DAT), dopamine receptor regulating factor (DRRF), or dopamine D2 receptor (DRD2) mRNA in the brain between Rasgrf2 KO and WT mice. After sub-chronic alcohol treatment, DAT and DRRF, but not DRD2 mRNA expression differed between WT and Rasgrf2 KO mice. Brain adaptations were positively correlated with splenic expression levels. These data suggest that Rasgrf2 controls dopaminergic signalling and adaptations to alcohol also in other brain regions, beyond the nucleus accumbens.

U2 - 10.1016/j.brainresbull.2014.10.008

DO - 10.1016/j.brainresbull.2014.10.008

M3 - Article

C2 - 25454123

VL - 109

SP - 143

EP - 150

JO - Brain Research Bulletin

JF - Brain Research Bulletin

SN - 0361-9230

ER -

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