Reactive angioendotheliomatosis in association with the antiphospholipid syndrome

D Creamer; M M Black; E Calonje

doi:10.1016/S0190-9622(00)90269-X

Reactive angioendotheliomatosis in association with the antiphospholipid syndrome

D Creamer, M M Black, E Calonje

King's College London

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

A 50-year-old woman with systemic lupus erythematosus developed extensive necrotic skin lesions on her chest and abdomen after the discontinuation of warfarin. The presence of antiphospholipid antibodies suggested a diagnosis of antiphospholipid syndrome. Histopathology from a skin lesion demonstrated marked expansion of the dermal microvasculature by intravascular cellular proliferation and focal thrombosis. The intravascular cells stained positive for the endothelial cell markers CD31 and factor VIII-associated antigen confirming reactive angioendotheliomatosis (RAE). This report is the first to identify RAE occurring in the context of the antiphospholipid syndrome. We suggest that intravascular endothelial proliferation, in concert with thrombosis, contributed to the angio-occlusive pathology.

Original language	English
Pages (from-to)	903 - 906
Number of pages	4
Journal	Journal of the American Academy of Dermatology
Volume	42
Issue number	5
DOIs	https://doi.org/10.1016/S0190-9622(00)90269-X
Publication status	Published - May 2000

Access to Document

10.1016/S0190-9622(00)90269-X

Cite this

@article{52c6443c27074d428bf7fa6ffa7918aa,

title = "Reactive angioendotheliomatosis in association with the antiphospholipid syndrome",

abstract = "A 50-year-old woman with systemic lupus erythematosus developed extensive necrotic skin lesions on her chest and abdomen after the discontinuation of warfarin. The presence of antiphospholipid antibodies suggested a diagnosis of antiphospholipid syndrome. Histopathology from a skin lesion demonstrated marked expansion of the dermal microvasculature by intravascular cellular proliferation and focal thrombosis. The intravascular cells stained positive for the endothelial cell markers CD31 and factor VIII-associated antigen confirming reactive angioendotheliomatosis (RAE). This report is the first to identify RAE occurring in the context of the antiphospholipid syndrome. We suggest that intravascular endothelial proliferation, in concert with thrombosis, contributed to the angio-occlusive pathology.",

author = "D Creamer and Black, {M M} and E Calonje",

year = "2000",

month = may,

doi = "10.1016/S0190-9622(00)90269-X",

language = "English",

volume = "42",

pages = "903 -- 906",

journal = "Journal of the American Academy of Dermatology",

publisher = "Elsevier",

number = "5",

}

TY - JOUR

T1 - Reactive angioendotheliomatosis in association with the antiphospholipid syndrome

AU - Creamer, D

AU - Black, M M

AU - Calonje, E

PY - 2000/5

Y1 - 2000/5

N2 - A 50-year-old woman with systemic lupus erythematosus developed extensive necrotic skin lesions on her chest and abdomen after the discontinuation of warfarin. The presence of antiphospholipid antibodies suggested a diagnosis of antiphospholipid syndrome. Histopathology from a skin lesion demonstrated marked expansion of the dermal microvasculature by intravascular cellular proliferation and focal thrombosis. The intravascular cells stained positive for the endothelial cell markers CD31 and factor VIII-associated antigen confirming reactive angioendotheliomatosis (RAE). This report is the first to identify RAE occurring in the context of the antiphospholipid syndrome. We suggest that intravascular endothelial proliferation, in concert with thrombosis, contributed to the angio-occlusive pathology.

AB - A 50-year-old woman with systemic lupus erythematosus developed extensive necrotic skin lesions on her chest and abdomen after the discontinuation of warfarin. The presence of antiphospholipid antibodies suggested a diagnosis of antiphospholipid syndrome. Histopathology from a skin lesion demonstrated marked expansion of the dermal microvasculature by intravascular cellular proliferation and focal thrombosis. The intravascular cells stained positive for the endothelial cell markers CD31 and factor VIII-associated antigen confirming reactive angioendotheliomatosis (RAE). This report is the first to identify RAE occurring in the context of the antiphospholipid syndrome. We suggest that intravascular endothelial proliferation, in concert with thrombosis, contributed to the angio-occlusive pathology.

UR - http://www.scopus.com/inward/record.url?scp=0034106236&partnerID=8YFLogxK

U2 - 10.1016/S0190-9622(00)90269-X

DO - 10.1016/S0190-9622(00)90269-X

M3 - Article

VL - 42

SP - 903

EP - 906

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

IS - 5

ER -

Reactive angioendotheliomatosis in association with the antiphospholipid syndrome

Abstract

Access to Document

Other files and links

Fingerprint

Cite this