Real-time whole genome sequencing to guide patient-tailored therapy of SARS-CoV-2 infection

Luke Blagdon Snell; Adela Alcolea-Medina; Themis Charalampous; Christopher Alder; Tom G.S. Williams; Flavia  Flaviani; Rahul Batra; Prijay Bakrania; Rajeni Thangarajah; Stuart Neil; Claire van Nispen tot Pannerden; Alina Botgros; Emma J. Aarons; Sam T Douthwaite; Jonathan Edgeworth; Gaia Nebbia

doi:10.1093/cid/ciac864

Real-time whole genome sequencing to guide patient-tailored therapy of SARS-CoV-2 infection

Luke Blagdon Snell, Adela Alcolea-Medina, Themis Charalampous, Christopher Alder, Tom G.S. Williams, Flavia Flaviani, Rahul Batra, Prijay Bakrania, Rajeni Thangarajah, Stuart Neil, Claire van Nispen tot Pannerden, Alina Botgros, Emma J. Aarons, Sam T Douthwaite, Jonathan Edgeworth, Gaia Nebbia

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Abstract

The management of COVID-19 has become more complex due to the expansion of available therapies. The presence of SARS-CoV-2 variants and mutations further complicate treatment due to their differing susceptibilities to therapies. Here we outline the use of real-time whole genome sequencing to characterise infections and guide treatment decisions.

Original language	English
Journal	Clinical Infectious Diseases
DOIs	https://doi.org/10.1093/cid/ciac864
Publication status	Accepted/In press - 26 Oct 2022

Keywords

COVID-19
SARS-CoV-2
whole genome sequencing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/cid/ciac864

Real-time whole genome sequencing_SNELL_Accepted26October2022_GREEN AAMAccepted author manuscript, 159 KB

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Snell, L. B., Alcolea-Medina, A., Charalampous, T., Alder, C., Williams, T. G. S., Flaviani, F., Batra, R., Bakrania, P., Thangarajah, R., Neil, S., van Nispen tot Pannerden, C., Botgros, A., Aarons, E. J., Douthwaite, S. T., Edgeworth, J., & Nebbia, G. (Accepted/In press). Real-time whole genome sequencing to guide patient-tailored therapy of SARS-CoV-2 infection. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciac864

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abstract = "The management of COVID-19 has become more complex due to the expansion of available therapies. The presence of SARS-CoV-2 variants and mutations further complicate treatment due to their differing susceptibilities to therapies. Here we outline the use of real-time whole genome sequencing to characterise infections and guide treatment decisions.",

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Snell, LB , Alcolea-Medina, A , Charalampous, T, Alder, C, Williams, TGS, Flaviani, F, Batra, R, Bakrania, P, Thangarajah, R, Neil, S, van Nispen tot Pannerden, C, Botgros, A, Aarons, EJ, Douthwaite, ST, Edgeworth, J & Nebbia, G 2022, 'Real-time whole genome sequencing to guide patient-tailored therapy of SARS-CoV-2 infection', Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciac864

TY - JOUR

T1 - Real-time whole genome sequencing to guide patient-tailored therapy of SARS-CoV-2 infection

AU - Snell, Luke Blagdon

AU - Alcolea-Medina, Adela

AU - Charalampous, Themis

AU - Alder, Christopher

AU - Williams, Tom G.S.

AU - Flaviani, Flavia

AU - Batra, Rahul

AU - Bakrania, Prijay

AU - Thangarajah, Rajeni

AU - Neil, Stuart

AU - van Nispen tot Pannerden, Claire

AU - Botgros, Alina

AU - Aarons, Emma J.

AU - Douthwaite, Sam T

AU - Edgeworth, Jonathan

AU - Nebbia, Gaia

PY - 2022/10/26

Y1 - 2022/10/26

N2 - The management of COVID-19 has become more complex due to the expansion of available therapies. The presence of SARS-CoV-2 variants and mutations further complicate treatment due to their differing susceptibilities to therapies. Here we outline the use of real-time whole genome sequencing to characterise infections and guide treatment decisions.

AB - The management of COVID-19 has become more complex due to the expansion of available therapies. The presence of SARS-CoV-2 variants and mutations further complicate treatment due to their differing susceptibilities to therapies. Here we outline the use of real-time whole genome sequencing to characterise infections and guide treatment decisions.

KW - COVID-19

KW - SARS-CoV-2

KW - whole genome sequencing

U2 - 10.1093/cid/ciac864

DO - 10.1093/cid/ciac864

M3 - Article

SN - 1058-4838

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

ER -

Real-time whole genome sequencing to guide patient-tailored therapy of SARS-CoV-2 infection

Abstract

Keywords

UN SDGs

Access to Document

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Cite this