King's College London

Research portal

Real world implementation of precision psychiatry: a systematic review of barriers and facilitators.

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
JournalBrain Sciences
Accepted/In press11 Jul 2022


King's Authors


Background: Despite significant research progress surrounding precision medicine in psychiatry, there has been little tangible impact upon real-world clinical care. Objective: To identify barriers and facilitators affecting the real-world implementation of precision psychiatry.
Method: A PRISMA-compliant systematic literature search of primary research studies, conducted in the Web of Science, Cochrane Central Register of Controlled Trials, PsycINFO and OpenGrey databases. We included a qualitative data synthesis structured according to the ‘Consolidated Framework for Implementation Research’ (CFIR) key constructs.
Results: Of 93,886 records screened, 28 studies were suitable for inclusion. The included studies reported thirty-eight barriers and facilitators attributed to the CFIR constructs. Commonly reported barriers included: potential psychological harm to the service user (n=11), cost and time investments (n=9), potential economic and occupational harm to the service user (n=8), poor accuracy and utility of the model (n=8), and poor perceived competence in precision medicine amongst staff (n=7). The most highly reported facilitator was the availability of adequate competence and skills training for staff (n=7).
Conclusions: Psychiatry faces widespread challenges in the implementation of precision medicine methods. Innovative solutions are required at the level of the individual and the wider system to fulfill the translational gap and impact real-world care.

Download statistics

No data available

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454