Recent Developments in Engineering Non-Paralytic Botulinum Molecules for Therapeutic Applications

Aisha Zhantleuova; Charlotte Leese; Anna P. Andreou; Altynay Karimova; Guy Carpenter; Bazbek Davletov

doi:10.3390/toxins16040175

Recent Developments in Engineering Non-Paralytic Botulinum Molecules for Therapeutic Applications

Aisha Zhantleuova, Charlotte Leese, Anna P. Andreou, Altynay Karimova, Guy Carpenter, Bazbek Davletov^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

This review discusses the expanding application of botulinum neurotoxin in treating neurological conditions. The article specifically explores novel approaches to using non-paralytic botulinum molecules. These new molecules, such as BiTox or el-iBoNT, offer an alternative for patients who face limitations in using paralytic forms of botulinum neurotoxin due to concerns about muscle function loss. We highlight the research findings that confirm not only the effectiveness of these molecules but also their reduced paralytic effect. We also discuss a potential cause for the diminished paralytic action of these molecules, specifically changes in the spatial parameters of the new botulinum molecules. In summary, this article reviews the current research that enhances our understanding of the application of new botulinum neurotoxins in the context of common conditions and suggests new avenues for developing more efficient molecules.

Original language	English
Article number	175
Journal	Toxins
Volume	16
Issue number	4
DOIs	https://doi.org/10.3390/toxins16040175
Publication status	Published - Apr 2024

Keywords

botulinum neurotoxin
efficacy
non-paralytic molecules
safety
treatment

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10.3390/toxins16040175

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title = "Recent Developments in Engineering Non-Paralytic Botulinum Molecules for Therapeutic Applications",

abstract = "This review discusses the expanding application of botulinum neurotoxin in treating neurological conditions. The article specifically explores novel approaches to using non-paralytic botulinum molecules. These new molecules, such as BiTox or el-iBoNT, offer an alternative for patients who face limitations in using paralytic forms of botulinum neurotoxin due to concerns about muscle function loss. We highlight the research findings that confirm not only the effectiveness of these molecules but also their reduced paralytic effect. We also discuss a potential cause for the diminished paralytic action of these molecules, specifically changes in the spatial parameters of the new botulinum molecules. In summary, this article reviews the current research that enhances our understanding of the application of new botulinum neurotoxins in the context of common conditions and suggests new avenues for developing more efficient molecules.",

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author = "Aisha Zhantleuova and Charlotte Leese and Andreou, {Anna P.} and Altynay Karimova and Guy Carpenter and Bazbek Davletov",

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T1 - Recent Developments in Engineering Non-Paralytic Botulinum Molecules for Therapeutic Applications

AU - Zhantleuova, Aisha

AU - Leese, Charlotte

AU - Andreou, Anna P.

AU - Karimova, Altynay

AU - Carpenter, Guy

AU - Davletov, Bazbek

PY - 2024/4

Y1 - 2024/4

N2 - This review discusses the expanding application of botulinum neurotoxin in treating neurological conditions. The article specifically explores novel approaches to using non-paralytic botulinum molecules. These new molecules, such as BiTox or el-iBoNT, offer an alternative for patients who face limitations in using paralytic forms of botulinum neurotoxin due to concerns about muscle function loss. We highlight the research findings that confirm not only the effectiveness of these molecules but also their reduced paralytic effect. We also discuss a potential cause for the diminished paralytic action of these molecules, specifically changes in the spatial parameters of the new botulinum molecules. In summary, this article reviews the current research that enhances our understanding of the application of new botulinum neurotoxins in the context of common conditions and suggests new avenues for developing more efficient molecules.

AB - This review discusses the expanding application of botulinum neurotoxin in treating neurological conditions. The article specifically explores novel approaches to using non-paralytic botulinum molecules. These new molecules, such as BiTox or el-iBoNT, offer an alternative for patients who face limitations in using paralytic forms of botulinum neurotoxin due to concerns about muscle function loss. We highlight the research findings that confirm not only the effectiveness of these molecules but also their reduced paralytic effect. We also discuss a potential cause for the diminished paralytic action of these molecules, specifically changes in the spatial parameters of the new botulinum molecules. In summary, this article reviews the current research that enhances our understanding of the application of new botulinum neurotoxins in the context of common conditions and suggests new avenues for developing more efficient molecules.

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KW - efficacy

KW - non-paralytic molecules

KW - safety

KW - treatment

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Recent Developments in Engineering Non-Paralytic Botulinum Molecules for Therapeutic Applications

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Keywords

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