Recent Progress and Future Direction for the Application of Multiomics Data in Clinical Liver Transplantation

Zhengtao Liu, Jun Xu, Shuping Que, Lei Geng, Lin Zhou, Adil Mardinoglu*, Shusen Zheng

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)

Abstract

Omics data address key issues in liver transplantation (LT) as the most effective therapeutic means for end-stage liver disease. The purpose of this study was to review the current application and future direction for omics in LT. We reviewed the use of multiomics to elucidate the pathogenesis leading to LT and prognostication. Future directions with respect to the use of omics in LT are also described based on perspectives of surgeons with experience in omics. Significant molecules were identified and summarized based on omics, with a focus on post-transplant liver fibrosis, early allograft dysfunction, tumor recurrence, and graft failure. We emphasized the importance omics for clinicians who perform LTs and prioritized the directions that should be established. We also outlined the ideal workflow for omics in LT. In step with advances in technology, the quality of omics data can be guaranteed using an improved algorithm at a lower price. Concerns should be addressed on the translational value of omics for better therapeutic effects in patients undergoing LT.

Original languageEnglish
Pages (from-to)363-373
Number of pages11
JournalJournal of Clinical and Translational Hepatology
Volume10
Issue number2
DOIs
Publication statusPublished - Apr 2022

Keywords

  • EAD
  • Liver transplantation
  • Metabolomics
  • Multiomic analysis
  • Proteomics
  • Transcriptomics

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