Recent progress in [11C]carbon dioxide ([11C]CO2) and [11C]carbon monoxide ([11C]CO) chemistry

Carlotta Taddei, Antony D. Gee*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)


Abstracts: [11C]Carbon dioxide ([11C]CO2) and [11C]carbon monoxide ([11C]CO) are 2 attractive precursors for labelling the carbonyl position (CO) in a vast range of functionalised molecules (eg, ureas, amides, and carboxylic acids). The development of radiosynthetic methods to produce functionalised 11C-labelled compounds is required to enhance the radiotracers available for positron emission tomography, molecular, and medical imaging applications. Following a brief summary of secondary 11C-precursor production and uses, the review focuses on recent progress with direct 11C-carboxylation routes with [11C]CO2 and 11C-carbonylation with [11C]CO. Novel approaches to generate [11C]CO using CO-releasing molecules (CO-RMs), such as silacarboxylic acids and disilanes, applied to radiochemistry are described and compared with standard [11C]CO production methods. These innovative [11C]CO synthesis strategies represent efficient and reliable [11C]CO production processes, enabling the widespread use of [11C]CO chemistry within the wider radiochemistry community.

Original languageEnglish
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Early online date5 Feb 2018
Publication statusE-pub ahead of print - 5 Feb 2018


  • C-carbonylation
  • C-carboxylation
  • C-labelling
  • Carbon-11
  • CO-releasing molecules
  • PET
  • [C]CO


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