Recommendations for standardizing nomenclature for dietary (poly)phenol catabolites

Colin D Kay; Michael N Clifford; Pedro Mena; Gordon J McDougall; Cristina Andres-Lacueva; Aedin Cassidy; Daniele Del Rio; Nikolai Kuhnert; Claudine Manach; Gema Pereira-Caro; Ana Rodriguez-Mateos; Augustin Scalbert; Francisco Tomás-Barberán; Gary Williamson; David S Wishart; Alan Crozier

doi:10.1093/ajcn/nqaa204

Recommendations for standardizing nomenclature for dietary (poly)phenol catabolites

Colin D Kay, Michael N Clifford, Pedro Mena, Gordon J McDougall, Cristina Andres-Lacueva, Aedin Cassidy, Daniele Del Rio, Nikolai Kuhnert, Claudine Manach, Gema Pereira-Caro, Ana Rodriguez-Mateos, Augustin Scalbert, Francisco Tomás-Barberán, Gary Williamson, David S Wishart, Alan Crozier

Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

There is a lack of focus on the protective health effects of phytochemicals in dietary guidelines. Although a number of chemical libraries and databases contain dietary phytochemicals belonging to the plant metabolome, they are not entirely relevant to human health because many constituents are extensively metabolized within the body following ingestion. This is especially apparent for the highly abundant dietary (poly)phenols, for which the situation is compounded by confusion regarding their bioavailability and metabolism, partially because of the variety of nomenclatures and trivial names used to describe compounds arising from microbial catabolism in the gastrointestinal tract. This confusion, which is perpetuated in online chemical/metabolite databases, will hinder future discovery of bioactivities and affect the establishment of future dietary guidelines if steps are not taken to overcome these issues. In order to resolve this situation, a nomenclature system for phenolic catabolites and their human phase II metabolites is proposed in this article and the basis of its format outlined. Previous names used in the literature are cited along with the recommended nomenclature, International Union of Pure and Applied Chemistry terminology, and, where appropriate, Chemical Abstracts Service numbers, InChIKey, and accurate mass.

Original language	English
Pages (from-to)	1051-1068
Number of pages	18
Journal	The American journal of clinical nutrition
Volume	112
Issue number	4
Early online date	16 Sept 2020
DOIs	https://doi.org/10.1093/ajcn/nqaa204
Publication status	Published - 1 Oct 2020

Keywords

dietary (poly)phenols
food/diet metabolome
microbial catabolites
nomenclature
phase II metabolites

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ajcn/nqaa204

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Kay, C. D., Clifford, M. N., Mena, P., McDougall, G. J., Andres-Lacueva, C., Cassidy, A., Del Rio, D., Kuhnert, N., Manach, C., Pereira-Caro, G., Rodriguez-Mateos, A., Scalbert, A., Tomás-Barberán, F., Williamson, G., Wishart, D. S., & Crozier, A. (2020). Recommendations for standardizing nomenclature for dietary (poly)phenol catabolites. The American journal of clinical nutrition, 112(4), 1051-1068. https://doi.org/10.1093/ajcn/nqaa204

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abstract = "There is a lack of focus on the protective health effects of phytochemicals in dietary guidelines. Although a number of chemical libraries and databases contain dietary phytochemicals belonging to the plant metabolome, they are not entirely relevant to human health because many constituents are extensively metabolized within the body following ingestion. This is especially apparent for the highly abundant dietary (poly)phenols, for which the situation is compounded by confusion regarding their bioavailability and metabolism, partially because of the variety of nomenclatures and trivial names used to describe compounds arising from microbial catabolism in the gastrointestinal tract. This confusion, which is perpetuated in online chemical/metabolite databases, will hinder future discovery of bioactivities and affect the establishment of future dietary guidelines if steps are not taken to overcome these issues. In order to resolve this situation, a nomenclature system for phenolic catabolites and their human phase II metabolites is proposed in this article and the basis of its format outlined. Previous names used in the literature are cited along with the recommended nomenclature, International Union of Pure and Applied Chemistry terminology, and, where appropriate, Chemical Abstracts Service numbers, InChIKey, and accurate mass.",

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Kay, CD, Clifford, MN, Mena, P, McDougall, GJ, Andres-Lacueva, C, Cassidy, A, Del Rio, D, Kuhnert, N, Manach, C, Pereira-Caro, G, Rodriguez-Mateos, A, Scalbert, A, Tomás-Barberán, F, Williamson, G, Wishart, DS & Crozier, A 2020, 'Recommendations for standardizing nomenclature for dietary (poly)phenol catabolites', The American journal of clinical nutrition, vol. 112, no. 4, pp. 1051-1068. https://doi.org/10.1093/ajcn/nqaa204

TY - JOUR

T1 - Recommendations for standardizing nomenclature for dietary (poly)phenol catabolites

AU - Kay, Colin D

AU - Clifford, Michael N

AU - Mena, Pedro

AU - McDougall, Gordon J

AU - Andres-Lacueva, Cristina

AU - Cassidy, Aedin

AU - Del Rio, Daniele

AU - Kuhnert, Nikolai

AU - Manach, Claudine

AU - Pereira-Caro, Gema

AU - Rodriguez-Mateos, Ana

AU - Scalbert, Augustin

AU - Tomás-Barberán, Francisco

AU - Williamson, Gary

AU - Wishart, David S

AU - Crozier, Alan

PY - 2020/10/1

Y1 - 2020/10/1

N2 - There is a lack of focus on the protective health effects of phytochemicals in dietary guidelines. Although a number of chemical libraries and databases contain dietary phytochemicals belonging to the plant metabolome, they are not entirely relevant to human health because many constituents are extensively metabolized within the body following ingestion. This is especially apparent for the highly abundant dietary (poly)phenols, for which the situation is compounded by confusion regarding their bioavailability and metabolism, partially because of the variety of nomenclatures and trivial names used to describe compounds arising from microbial catabolism in the gastrointestinal tract. This confusion, which is perpetuated in online chemical/metabolite databases, will hinder future discovery of bioactivities and affect the establishment of future dietary guidelines if steps are not taken to overcome these issues. In order to resolve this situation, a nomenclature system for phenolic catabolites and their human phase II metabolites is proposed in this article and the basis of its format outlined. Previous names used in the literature are cited along with the recommended nomenclature, International Union of Pure and Applied Chemistry terminology, and, where appropriate, Chemical Abstracts Service numbers, InChIKey, and accurate mass.

AB - There is a lack of focus on the protective health effects of phytochemicals in dietary guidelines. Although a number of chemical libraries and databases contain dietary phytochemicals belonging to the plant metabolome, they are not entirely relevant to human health because many constituents are extensively metabolized within the body following ingestion. This is especially apparent for the highly abundant dietary (poly)phenols, for which the situation is compounded by confusion regarding their bioavailability and metabolism, partially because of the variety of nomenclatures and trivial names used to describe compounds arising from microbial catabolism in the gastrointestinal tract. This confusion, which is perpetuated in online chemical/metabolite databases, will hinder future discovery of bioactivities and affect the establishment of future dietary guidelines if steps are not taken to overcome these issues. In order to resolve this situation, a nomenclature system for phenolic catabolites and their human phase II metabolites is proposed in this article and the basis of its format outlined. Previous names used in the literature are cited along with the recommended nomenclature, International Union of Pure and Applied Chemistry terminology, and, where appropriate, Chemical Abstracts Service numbers, InChIKey, and accurate mass.

KW - dietary (poly)phenols

KW - food/diet metabolome

KW - microbial catabolites

KW - nomenclature

KW - phase II metabolites

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U2 - 10.1093/ajcn/nqaa204

DO - 10.1093/ajcn/nqaa204

M3 - Article

C2 - 32936878

SN - 0002-9165

VL - 112

SP - 1051

EP - 1068

JO - The American journal of clinical nutrition

JF - The American journal of clinical nutrition

IS - 4

ER -

Recommendations for standardizing nomenclature for dietary (poly)phenol catabolites

Abstract

Keywords

UN SDGs

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