TY - JOUR
T1 - Reconstructing contralateral fiber tracts
T2 - Methodological aspects of cerebello-thalamo-cortical pathway reconstruction
AU - Palesi, Fulvia
AU - Tournier, Jacques Donald
AU - Calamante, Fernando
AU - Muhlert, Nils
AU - Castellazzi, Gloria
AU - Chard, Declan
AU - D’Angelo, Egidio
AU - Wheeler-Kingshott, Claudia Gandini
PY - 2016/10/1
Y1 - 2016/10/1
N2 - The identification of pathways connecting the cerebral cortex with subcortical structures is critical to understanding how large-scale brain networks operate. The cerebellum, for example, is known to project numerous axonal bundles to the cerebral cortex passing through the thalamus. This paper focuses on the technical details of cerebello-thalamo-cortical pathway reconstruction using advanced diffusion MRI techniques in humans in vivo. Pathways reconstructed using seed/target placement on super-resolution maps, created with track density imaging (TDI), were compared with those reconstructed by defining regions of interest (ROIs) on non-diffusion weighted images (bO). We observed that the reconstruction of the pathways was more anatomically accurate when using ROIs placed on TDI rather than on bO maps, while inter-subject variability and reproducibility were similar between the two methods. Diffusion indices along pathways showed a position-dependent specificity that will need to be taken into consideration in future clinical investigations.
AB - The identification of pathways connecting the cerebral cortex with subcortical structures is critical to understanding how large-scale brain networks operate. The cerebellum, for example, is known to project numerous axonal bundles to the cerebral cortex passing through the thalamus. This paper focuses on the technical details of cerebello-thalamo-cortical pathway reconstruction using advanced diffusion MRI techniques in humans in vivo. Pathways reconstructed using seed/target placement on super-resolution maps, created with track density imaging (TDI), were compared with those reconstructed by defining regions of interest (ROIs) on non-diffusion weighted images (bO). We observed that the reconstruction of the pathways was more anatomically accurate when using ROIs placed on TDI rather than on bO maps, while inter-subject variability and reproducibility were similar between the two methods. Diffusion indices along pathways showed a position-dependent specificity that will need to be taken into consideration in future clinical investigations.
KW - Cerebello-thalamo-cortical pathway
KW - Constrained spherical deconvolution
KW - Diffusion MRI
KW - Super-resolution
KW - Track-density imaging
UR - http://www.scopus.com/inward/record.url?scp=85009507890&partnerID=8YFLogxK
U2 - 10.11138/FNeur/2016.31.4.229
DO - 10.11138/FNeur/2016.31.4.229
M3 - Article
AN - SCOPUS:85009507890
SN - 0393-5264
VL - 31
SP - 229
EP - 238
JO - Functional Neurology
JF - Functional Neurology
IS - 4
ER -