Reconstructing contralateral fiber tracts: methodological aspects of cerebello-thalamocortical pathway reconstruction

Fulvia Palesi; Jacques-Donald Tournier; F Calamante; Nils Muhlert; Gloria Castellazzi; Declan Chard; E D'Angelo; Claudia Gandini Wheeler-Kingshott

Reconstructing contralateral fiber tracts: methodological aspects of cerebello-thalamocortical pathway reconstruction

Fulvia Palesi, Jacques-Donald Tournier, F Calamante, Nils Muhlert, Gloria Castellazzi, Declan Chard, E D'Angelo, Claudia Gandini Wheeler-Kingshott

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Abstract

The identification of pathways connecting the cerebral cortex with subcortical structures is critical to understanding how large-scale brain networks operate. The cerebellum, for example, is known to project numerous axonal bundles to thecerebral cortex passing through the thalamus. This paper focuses on the technical details of cerebello-thalamo-cortical pathway reconstruction using advanced diffusion MRI techniques in humans in vivo. Pathways reconstructed using seed/target placement on super-resolution maps, created with track density imaging (TDI), were compared with those reconstructed by defining regions of interest (ROIs) on non-diffusion weighted images (b0). We observed that the reconstruction of the pathways was more anatomically accurate when using ROIs placed on TDI rather than on b0 maps, while inter-subject variability and reproducibility were similar between the two methods. Diffusion indices along pathways showed a position-dependent specificity that will need to be taken into consideration in future clinical investigations.

Original language	English
Pages (from-to)	1-10
Number of pages	10
Journal	Functional Neurology
Volume	31
Issue number	2
Publication status	Published - 4 May 2015

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Palesi, F., Tournier, J.-D., Calamante, F., Muhlert, N., Castellazzi, G., Chard, D., D'Angelo, E., & Wheeler-Kingshott, C. G. (2015). Reconstructing contralateral fiber tracts: methodological aspects of cerebello-thalamocortical pathway reconstruction. Functional Neurology, 31(2), 1-10. http://www.functionalneurology.com/common/php/portiere.php?ID=fb2efa12e360ed367dc59917665f3159

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title = "Reconstructing contralateral fiber tracts: methodological aspects of cerebello-thalamocortical pathway reconstruction",

abstract = "The identification of pathways connecting the cerebral cortex with subcortical structures is critical to understanding how large-scale brain networks operate. The cerebellum, for example, is known to project numerous axonal bundles to thecerebral cortex passing through the thalamus. This paper focuses on the technical details of cerebello-thalamo-cortical pathway reconstruction using advanced diffusion MRI techniques in humans in vivo. Pathways reconstructed using seed/target placement on super-resolution maps, created with track density imaging (TDI), were compared with those reconstructed by defining regions of interest (ROIs) on non-diffusion weighted images (b0). We observed that the reconstruction of the pathways was more anatomically accurate when using ROIs placed on TDI rather than on b0 maps, while inter-subject variability and reproducibility were similar between the two methods. Diffusion indices along pathways showed a position-dependent specificity that will need to be taken into consideration in future clinical investigations.",

author = "Fulvia Palesi and Jacques-Donald Tournier and F Calamante and Nils Muhlert and Gloria Castellazzi and Declan Chard and E D'Angelo and Wheeler-Kingshott, {Claudia Gandini}",

year = "2015",

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Palesi, F, Tournier, J-D, Calamante, F, Muhlert, N, Castellazzi, G, Chard, D, D'Angelo, E & Wheeler-Kingshott, CG 2015, 'Reconstructing contralateral fiber tracts: methodological aspects of cerebello-thalamocortical pathway reconstruction', Functional Neurology, vol. 31, no. 2, pp. 1-10. <http://www.functionalneurology.com/common/php/portiere.php?ID=fb2efa12e360ed367dc59917665f3159>

TY - JOUR

T1 - Reconstructing contralateral fiber tracts

T2 - methodological aspects of cerebello-thalamocortical pathway reconstruction

AU - Palesi, Fulvia

AU - Tournier, Jacques-Donald

AU - Calamante, F

AU - Muhlert, Nils

AU - Castellazzi, Gloria

AU - Chard, Declan

AU - D'Angelo, E

AU - Wheeler-Kingshott, Claudia Gandini

PY - 2015/5/4

Y1 - 2015/5/4

N2 - The identification of pathways connecting the cerebral cortex with subcortical structures is critical to understanding how large-scale brain networks operate. The cerebellum, for example, is known to project numerous axonal bundles to thecerebral cortex passing through the thalamus. This paper focuses on the technical details of cerebello-thalamo-cortical pathway reconstruction using advanced diffusion MRI techniques in humans in vivo. Pathways reconstructed using seed/target placement on super-resolution maps, created with track density imaging (TDI), were compared with those reconstructed by defining regions of interest (ROIs) on non-diffusion weighted images (b0). We observed that the reconstruction of the pathways was more anatomically accurate when using ROIs placed on TDI rather than on b0 maps, while inter-subject variability and reproducibility were similar between the two methods. Diffusion indices along pathways showed a position-dependent specificity that will need to be taken into consideration in future clinical investigations.

AB - The identification of pathways connecting the cerebral cortex with subcortical structures is critical to understanding how large-scale brain networks operate. The cerebellum, for example, is known to project numerous axonal bundles to thecerebral cortex passing through the thalamus. This paper focuses on the technical details of cerebello-thalamo-cortical pathway reconstruction using advanced diffusion MRI techniques in humans in vivo. Pathways reconstructed using seed/target placement on super-resolution maps, created with track density imaging (TDI), were compared with those reconstructed by defining regions of interest (ROIs) on non-diffusion weighted images (b0). We observed that the reconstruction of the pathways was more anatomically accurate when using ROIs placed on TDI rather than on b0 maps, while inter-subject variability and reproducibility were similar between the two methods. Diffusion indices along pathways showed a position-dependent specificity that will need to be taken into consideration in future clinical investigations.

M3 - Article

C2 - 27142701

SN - 0393-5264

VL - 31

SP - 1

EP - 10

JO - Functional Neurology

JF - Functional Neurology

IS - 2

ER -

Reconstructing contralateral fiber tracts: methodological aspects of cerebello-thalamocortical pathway reconstruction

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