Recruitment of transcription complexes to enhancers and the role of enhancer transcription

TY - JOUR

T1 - Recruitment of transcription complexes to enhancers and the role of enhancer transcription

AU - Stees, Jared S

AU - Varn, Fred

AU - Huang, Suming

AU - Strouboulis, John

AU - Bungert, Jörg

PY - 2012/12/5

Y1 - 2012/12/5

N2 - Enhancer elements regulate the tissue- and developmental-stage-specific expression of genes. Recent estimates suggest that there are more than 50,000 enhancers in mammalian cells. At least a subset of enhancers has been shown to recruit RNA polymerase II transcription complexes and to generate enhancer transcripts. Here, we provide an overview of enhancer function and discuss how transcription of enhancers or enhancer-generated transcripts could contribute to the regulation of gene expression during development and differentiation.

AB - Enhancer elements regulate the tissue- and developmental-stage-specific expression of genes. Recent estimates suggest that there are more than 50,000 enhancers in mammalian cells. At least a subset of enhancers has been shown to recruit RNA polymerase II transcription complexes and to generate enhancer transcripts. Here, we provide an overview of enhancer function and discuss how transcription of enhancers or enhancer-generated transcripts could contribute to the regulation of gene expression during development and differentiation.

U2 - 10.3390/biology1030778

DO - 10.3390/biology1030778

M3 - Article

C2 - 23919179

SN - 2079-7737

VL - 1

SP - 778

EP - 793

JO - Biology

JF - Biology

IS - 3

ER -