Redox-active metal complexes for imaging hypoxic tissues: structure-activity relationships in copper(II) bis(thiosemicarbazone) complexes

J L J  Dearling; J S  Lewis; D W  McCarthy; M J  Welch; P J  Blower

Redox-active metal complexes for imaging hypoxic tissues: structure-activity relationships in copper(II) bis(thiosemicarbazone) complexes

J L J Dearling, J S Lewis, D W McCarthy, M J Welch, P J Blower

University of Kent

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160 Citations (Scopus)

Abstract

Reduction potential and lipophilicity of the copper(II) bis(thiosemicarbazone) complexes can be independently controlled by alkylation in the diketone backbone and the N-termini of the ligand, allowing optimisation of radiopharmaceuticals strongly selective for hypoxic tissues.

Original language	English
Pages (from-to)	2531-2532
Number of pages	2
Journal	CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY
Issue number	22
Publication status	Published - 21 Nov 1998

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Dearling, J. L. J., Lewis, J. S., McCarthy, D. W., Welch, M. J., & Blower, P. J. (1998). Redox-active metal complexes for imaging hypoxic tissues: structure-activity relationships in copper(II) bis(thiosemicarbazone) complexes. CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY, (22), 2531-2532. http://pubs.rsc.org/en/content/articlelanding/cc/1998/a805957h#!divAbstract

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abstract = "Reduction potential and lipophilicity of the copper(II) bis(thiosemicarbazone) complexes can be independently controlled by alkylation in the diketone backbone and the N-termini of the ligand, allowing optimisation of radiopharmaceuticals strongly selective for hypoxic tissues.",

author = "Dearling, {J L J} and Lewis, {J S} and McCarthy, {D W} and Welch, {M J} and Blower, {P J}",

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AU - Dearling, J L J

AU - Lewis, J S

AU - McCarthy, D W

AU - Welch, M J

AU - Blower, P J

PY - 1998/11/21

Y1 - 1998/11/21

N2 - Reduction potential and lipophilicity of the copper(II) bis(thiosemicarbazone) complexes can be independently controlled by alkylation in the diketone backbone and the N-termini of the ligand, allowing optimisation of radiopharmaceuticals strongly selective for hypoxic tissues.

AB - Reduction potential and lipophilicity of the copper(II) bis(thiosemicarbazone) complexes can be independently controlled by alkylation in the diketone backbone and the N-termini of the ligand, allowing optimisation of radiopharmaceuticals strongly selective for hypoxic tissues.

M3 - Article

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SP - 2531

EP - 2532

JO - CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY

JF - CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY

IS - 22

ER -

Redox-active metal complexes for imaging hypoxic tissues: structure-activity relationships in copper(II) bis(thiosemicarbazone) complexes

Abstract

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