Redox signaling in cardiac myocytes

Research output: Contribution to journalLiterature reviewpeer-review

271 Citations (Scopus)

Abstract

The heart has complex mechanisms that facilitate the maintenance of an oxygen supply-demand balance necessary for its contractile function an response to physiological fluctuations in workload as well as in response to chronic stresses such as hypoxia, ischemia, and overload. Redox-sensitive signaling pathways are centrally involved in many of these homeostatic and stress-response mechanisms. Here, we review the main redox-regulated pathways that are involved in cardiac myocyte excitation-contraction coupling, differentiation, hypertrophy, and stress responses. We discuss specific sources of endogenously generated reactive oxygen species (e.g., mitochondria and NADPH oxidases of the Nox family), the particular pathways and processes that they affect, the role of modulators such as thioredoxin, and the specific molecular mechanisms that are involved where this knowledge is available. A better understanding of this complex regulatory system may allow the development of more specific therapeutic strategies for heart diseases.
Original languageEnglish
Pages (from-to)777 - 793
Number of pages17
JournalFree Radical Biology and Medicine
Volume50
Issue number7
DOIs
Publication statusPublished - 1 Apr 2011

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