Redox signaling in cardiac myocytes

Celio Santos Xavier Da Costa Dos Santos; Narayana Anilkumar; Min Zhang; Alison C. Brewer; Ajay M. Shah

doi:10.1016/j.freeradbiomed.2011.01.003

Redox signaling in cardiac myocytes

Celio Santos Xavier Da Costa Dos Santos, Narayana Anilkumar, Min Zhang, Alison C. Brewer, Ajay M. Shah

Cardiovascular Sciences

Research output: Contribution to journal › Literature review › peer-review

285 Citations (Scopus)

Abstract

The heart has complex mechanisms that facilitate the maintenance of an oxygen supply-demand balance necessary for its contractile function an response to physiological fluctuations in workload as well as in response to chronic stresses such as hypoxia, ischemia, and overload. Redox-sensitive signaling pathways are centrally involved in many of these homeostatic and stress-response mechanisms. Here, we review the main redox-regulated pathways that are involved in cardiac myocyte excitation-contraction coupling, differentiation, hypertrophy, and stress responses. We discuss specific sources of endogenously generated reactive oxygen species (e.g., mitochondria and NADPH oxidases of the Nox family), the particular pathways and processes that they affect, the role of modulators such as thioredoxin, and the specific molecular mechanisms that are involved where this knowledge is available. A better understanding of this complex regulatory system may allow the development of more specific therapeutic strategies for heart diseases.

Original language	English
Pages (from-to)	777 - 793
Number of pages	17
Journal	Free Radical Biology and Medicine
Volume	50
Issue number	7
DOIs	https://doi.org/10.1016/j.freeradbiomed.2011.01.003
Publication status	Published - 1 Apr 2011

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title = "Redox signaling in cardiac myocytes",

abstract = "The heart has complex mechanisms that facilitate the maintenance of an oxygen supply-demand balance necessary for its contractile function an response to physiological fluctuations in workload as well as in response to chronic stresses such as hypoxia, ischemia, and overload. Redox-sensitive signaling pathways are centrally involved in many of these homeostatic and stress-response mechanisms. Here, we review the main redox-regulated pathways that are involved in cardiac myocyte excitation-contraction coupling, differentiation, hypertrophy, and stress responses. We discuss specific sources of endogenously generated reactive oxygen species (e.g., mitochondria and NADPH oxidases of the Nox family), the particular pathways and processes that they affect, the role of modulators such as thioredoxin, and the specific molecular mechanisms that are involved where this knowledge is available. A better understanding of this complex regulatory system may allow the development of more specific therapeutic strategies for heart diseases.",

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T1 - Redox signaling in cardiac myocytes

AU - Xavier Da Costa Dos Santos, Celio Santos

AU - Anilkumar, Narayana

AU - Zhang, Min

AU - Brewer, Alison C.

AU - Shah, Ajay M.

PY - 2011/4/1

Y1 - 2011/4/1

N2 - The heart has complex mechanisms that facilitate the maintenance of an oxygen supply-demand balance necessary for its contractile function an response to physiological fluctuations in workload as well as in response to chronic stresses such as hypoxia, ischemia, and overload. Redox-sensitive signaling pathways are centrally involved in many of these homeostatic and stress-response mechanisms. Here, we review the main redox-regulated pathways that are involved in cardiac myocyte excitation-contraction coupling, differentiation, hypertrophy, and stress responses. We discuss specific sources of endogenously generated reactive oxygen species (e.g., mitochondria and NADPH oxidases of the Nox family), the particular pathways and processes that they affect, the role of modulators such as thioredoxin, and the specific molecular mechanisms that are involved where this knowledge is available. A better understanding of this complex regulatory system may allow the development of more specific therapeutic strategies for heart diseases.

AB - The heart has complex mechanisms that facilitate the maintenance of an oxygen supply-demand balance necessary for its contractile function an response to physiological fluctuations in workload as well as in response to chronic stresses such as hypoxia, ischemia, and overload. Redox-sensitive signaling pathways are centrally involved in many of these homeostatic and stress-response mechanisms. Here, we review the main redox-regulated pathways that are involved in cardiac myocyte excitation-contraction coupling, differentiation, hypertrophy, and stress responses. We discuss specific sources of endogenously generated reactive oxygen species (e.g., mitochondria and NADPH oxidases of the Nox family), the particular pathways and processes that they affect, the role of modulators such as thioredoxin, and the specific molecular mechanisms that are involved where this knowledge is available. A better understanding of this complex regulatory system may allow the development of more specific therapeutic strategies for heart diseases.

U2 - 10.1016/j.freeradbiomed.2011.01.003

DO - 10.1016/j.freeradbiomed.2011.01.003

M3 - Literature review

SN - 0891-5849

VL - 50

SP - 777

EP - 793

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

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ER -

Redox signaling in cardiac myocytes

Abstract

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