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Reduced cortical surface area in adolescents with conduct disorder

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Reduced cortical surface area in adolescents with conduct disorder. / Sarkar, Sagari; Daly, Eileen; Feng, Yue; Ecker, Christine; Craig, Michael C.; Harding, Duncan; Deeley, Quinton; Murphy, Declan G M.

In: European Child and Adolescent Psychiatry, Vol. 24, No. 8, 08.2015, p. 909-917.

Research output: Contribution to journalArticle

Harvard

Sarkar, S, Daly, E, Feng, Y, Ecker, C, Craig, MC, Harding, D, Deeley, Q & Murphy, DGM 2015, 'Reduced cortical surface area in adolescents with conduct disorder', European Child and Adolescent Psychiatry, vol. 24, no. 8, pp. 909-917. https://doi.org/10.1007/s00787-014-0639-3

APA

Sarkar, S., Daly, E., Feng, Y., Ecker, C., Craig, M. C., Harding, D., ... Murphy, D. G. M. (2015). Reduced cortical surface area in adolescents with conduct disorder. European Child and Adolescent Psychiatry, 24(8), 909-917. https://doi.org/10.1007/s00787-014-0639-3

Vancouver

Sarkar S, Daly E, Feng Y, Ecker C, Craig MC, Harding D et al. Reduced cortical surface area in adolescents with conduct disorder. European Child and Adolescent Psychiatry. 2015 Aug;24(8):909-917. https://doi.org/10.1007/s00787-014-0639-3

Author

Sarkar, Sagari ; Daly, Eileen ; Feng, Yue ; Ecker, Christine ; Craig, Michael C. ; Harding, Duncan ; Deeley, Quinton ; Murphy, Declan G M. / Reduced cortical surface area in adolescents with conduct disorder. In: European Child and Adolescent Psychiatry. 2015 ; Vol. 24, No. 8. pp. 909-917.

Bibtex Download

@article{9bc83e7c938c493d841e87e62a1985c2,
title = "Reduced cortical surface area in adolescents with conduct disorder",
abstract = "Children with conduct disorder (CD) are at increased risk of developing antisocial personality disorder and psychopathy in adulthood. Neuroimaging research has identified abnormal cortical volume (CV) in CD. However, CV comprises two genetically and developmentally separable components: cortical thickness (CT) and surface area (SA). Aim of this study is to explore the relationship between the cortical constituents of CV in boys with CD. We applied FreeSurfer software to structural MRI data to derive measures of CV, CT, and SA in 21 boys with CD and 19 controls. Relationships between these cortical measures were investigated. Boys with CD had significantly reduced CV and SA compared to non-CD boys in ventromedial and dorsolateral prefrontal cortex. We found no significant between-group differences in CT. Reduced prefrontal CV in boys with CD is associated with significantly reduced SA in the same regions. This finding may help to identify specific neurodevelopmental mechanisms underlying cortical deficits observed in CD.",
keywords = "Brain anatomy, Conduct disorder, Cortical thickness, Cortical volume, Surface area, Surface based morphometry",
author = "Sagari Sarkar and Eileen Daly and Yue Feng and Christine Ecker and Craig, {Michael C.} and Duncan Harding and Quinton Deeley and Murphy, {Declan G M}",
year = "2015",
month = "8",
doi = "10.1007/s00787-014-0639-3",
language = "English",
volume = "24",
pages = "909--917",
journal = "European Child and Adolescent Psychiatry",
issn = "1018-8827",
number = "8",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Reduced cortical surface area in adolescents with conduct disorder

AU - Sarkar, Sagari

AU - Daly, Eileen

AU - Feng, Yue

AU - Ecker, Christine

AU - Craig, Michael C.

AU - Harding, Duncan

AU - Deeley, Quinton

AU - Murphy, Declan G M

PY - 2015/8

Y1 - 2015/8

N2 - Children with conduct disorder (CD) are at increased risk of developing antisocial personality disorder and psychopathy in adulthood. Neuroimaging research has identified abnormal cortical volume (CV) in CD. However, CV comprises two genetically and developmentally separable components: cortical thickness (CT) and surface area (SA). Aim of this study is to explore the relationship between the cortical constituents of CV in boys with CD. We applied FreeSurfer software to structural MRI data to derive measures of CV, CT, and SA in 21 boys with CD and 19 controls. Relationships between these cortical measures were investigated. Boys with CD had significantly reduced CV and SA compared to non-CD boys in ventromedial and dorsolateral prefrontal cortex. We found no significant between-group differences in CT. Reduced prefrontal CV in boys with CD is associated with significantly reduced SA in the same regions. This finding may help to identify specific neurodevelopmental mechanisms underlying cortical deficits observed in CD.

AB - Children with conduct disorder (CD) are at increased risk of developing antisocial personality disorder and psychopathy in adulthood. Neuroimaging research has identified abnormal cortical volume (CV) in CD. However, CV comprises two genetically and developmentally separable components: cortical thickness (CT) and surface area (SA). Aim of this study is to explore the relationship between the cortical constituents of CV in boys with CD. We applied FreeSurfer software to structural MRI data to derive measures of CV, CT, and SA in 21 boys with CD and 19 controls. Relationships between these cortical measures were investigated. Boys with CD had significantly reduced CV and SA compared to non-CD boys in ventromedial and dorsolateral prefrontal cortex. We found no significant between-group differences in CT. Reduced prefrontal CV in boys with CD is associated with significantly reduced SA in the same regions. This finding may help to identify specific neurodevelopmental mechanisms underlying cortical deficits observed in CD.

KW - Brain anatomy

KW - Conduct disorder

KW - Cortical thickness

KW - Cortical volume

KW - Surface area

KW - Surface based morphometry

U2 - 10.1007/s00787-014-0639-3

DO - 10.1007/s00787-014-0639-3

M3 - Article

VL - 24

SP - 909

EP - 917

JO - European Child and Adolescent Psychiatry

JF - European Child and Adolescent Psychiatry

SN - 1018-8827

IS - 8

ER -

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