Reduced modelling of blood flow in the cerebral circulation: Coupling 1-D, 0-D and cerebral auto-regulation models

Jordi Alastruey; S. M. Moore; K. H. Parker; T. David; J. Peiro; S. J. Sherwin

doi:10.1002/fld.1606

Reduced modelling of blood flow in the cerebral circulation: Coupling 1-D, 0-D and cerebral auto-regulation models

Jordi Alastruey, S. M. Moore, K. H. Parker, T. David, J. Peiro, S. J. Sherwin

Biomedical Engineering Department

Research output: Contribution to journal › Article › peer-review

98 Citations (Scopus)

Abstract

Pulsatile blood flow in the cerebral circulation is simulated using a nonlinear, one-dimensional model of the arterial haemodynamics coupled in the time domain with lumped parameter and flow auto-regulation models of the perfusion of the microcirculation. A linear analysis of the coupling shows that a resistance equal to the characteristic impedance of the blood vessel is required at the inflow of a terminal windkessel model to avoid the generation of non-physiological wave reflections. The cerebral model suggests that the worst anatomical variation of the circle of Willis in terms of restoring normal cerebral flows after a sudden carotid occlusion is a circle without the first segment of the contralateral anterior cerebral artery. Copyright (C) 2007 John Wiley & Sons, Ltd.

Original language	English
Pages (from-to)	1061-1067
Number of pages	7
Journal	INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS
Volume	56
Issue number	8
DOIs	https://doi.org/10.1002/fld.1606
Publication status	Published - 20 Mar 2008

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abstract = "Pulsatile blood flow in the cerebral circulation is simulated using a nonlinear, one-dimensional model of the arterial haemodynamics coupled in the time domain with lumped parameter and flow auto-regulation models of the perfusion of the microcirculation. A linear analysis of the coupling shows that a resistance equal to the characteristic impedance of the blood vessel is required at the inflow of a terminal windkessel model to avoid the generation of non-physiological wave reflections. The cerebral model suggests that the worst anatomical variation of the circle of Willis in terms of restoring normal cerebral flows after a sudden carotid occlusion is a circle without the first segment of the contralateral anterior cerebral artery. Copyright (C) 2007 John Wiley & Sons, Ltd.",

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AU - Moore, S. M.

AU - Parker, K. H.

AU - David, T.

AU - Peiro, J.

AU - Sherwin, S. J.

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AB - Pulsatile blood flow in the cerebral circulation is simulated using a nonlinear, one-dimensional model of the arterial haemodynamics coupled in the time domain with lumped parameter and flow auto-regulation models of the perfusion of the microcirculation. A linear analysis of the coupling shows that a resistance equal to the characteristic impedance of the blood vessel is required at the inflow of a terminal windkessel model to avoid the generation of non-physiological wave reflections. The cerebral model suggests that the worst anatomical variation of the circle of Willis in terms of restoring normal cerebral flows after a sudden carotid occlusion is a circle without the first segment of the contralateral anterior cerebral artery. Copyright (C) 2007 John Wiley & Sons, Ltd.

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JF - INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS

IS - 8

ER -

Reduced modelling of blood flow in the cerebral circulation: Coupling 1-D, 0-D and cerebral auto-regulation models

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