Refining rodent models of spinal cord injury

Elliot Lilley*, Melissa R. Andrews, Elizabeth J. Bradbury, Heather Elliott, Penny Hawkins, Ronaldo M. Ichiyama, Jo Keeley, Adina T. Michael-Titus, Lawrence D.F. Moon, Stefano Pluchino, John Riddell, Kathy Ryder, Ping K. Yip

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)

Abstract

This report was produced by an Expert Working Group (EWG) consisting of UK-based researchers, veterinarians and regulators of animal experiments with specialist knowledge of the use of animal models of spinal cord injury (SCI). It aims to facilitate the implementation of the Three Rs (Replacement, Reduction and Refinement), with an emphasis on refinement. Specific animal welfare issues were identified and discussed, and practical measures proposed, with the aim of reducing animal use and suffering, reducing experimental variability, and increasing translatability within this critically important research field.

Original languageEnglish
Article number113273
JournalExperimental Neurology
Volume328
DOIs
Publication statusPublished - Jun 2020

Keywords

  • Animal model
  • Animal welfare
  • Paralysis
  • Refinement
  • Regeneration
  • Spinal contusion
  • Spinal cord injury
  • Spinal transection
  • Three Rs
  • Tissue repair
  • Translational research

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