Refining rodent models of spinal cord injury

Elliot Lilley; Melissa R. Andrews; Elizabeth J. Bradbury; Heather Elliott; Penny Hawkins; Ronaldo M. Ichiyama; Jo Keeley; Adina T. Michael-Titus; Lawrence D.F. Moon; Stefano Pluchino; John Riddell; Kathy Ryder; Ping K. Yip

doi:10.1016/j.expneurol.2020.113273

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Refining rodent models of spinal cord injury

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Elliot Lilley, Melissa R. Andrews, Elizabeth J. Bradbury, Heather Elliott, Penny Hawkins, Ronaldo M. Ichiyama, Jo Keeley, Adina T. Michael-Titus, Lawrence D.F. Moon, Stefano Pluchino, John Riddell, Kathy Ryder, Ping K. Yip

Original language	English
Article number	113273
Journal	Experimental Neurology
Volume	328
DOIs	https://doi.org/10.1016/j.expneurol.2020.113273
Published	Jun 2020
Additional links	Link to publication in Scopus

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Abstract

This report was produced by an Expert Working Group (EWG) consisting of UK-based researchers, veterinarians and regulators of animal experiments with specialist knowledge of the use of animal models of spinal cord injury (SCI). It aims to facilitate the implementation of the Three Rs (Replacement, Reduction and Refinement), with an emphasis on refinement. Specific animal welfare issues were identified and discussed, and practical measures proposed, with the aim of reducing animal use and suffering, reducing experimental variability, and increasing translatability within this critically important research field.

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Refining rodent models of spinal cord injury

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