Regenerating Eye Tissues to Preserve and Restore Vision

Jeffrey H. Stern, Yangzi Tian, James Funderburgh, Graziella Pellegrini, Kang Zhang, Jeffrey L. Goldberg, Robin R. Ali, Michael Young, Yubing Xie, Sally Temple*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

118 Citations (Scopus)

Abstract

Ocular regenerative therapies are on track to revolutionize treatment of numerous blinding disorders, including corneal disease, cataract, glaucoma, retinitis pigmentosa, and age-related macular degeneration. A variety of transplantable products, delivered as cell suspensions or as preformed 3D structures combining cells and natural or artificial substrates, are in the pipeline. Here we review the status of clinical and preclinical studies for stem cell-based repair, covering key eye tissues from front to back, from cornea to retina, and including bioengineering approaches that advance cell product manufacturing. While recognizing the challenges, we look forward to a deep portfolio of sight-restoring, stem cell-based medicine. Video Abstract:[Figure presented] Stern et al. review the status of clinical and preclinical studies for stem cell-based repair, covering key eye tissues from front to back, from cornea to retina, and including bioengineering approaches that advance cell product manufacturing.

Original languageEnglish
Pages (from-to)834-849
Number of pages16
JournalCell Stem Cell
Volume22
Issue number6
DOIs
Publication statusPublished - 1 Jun 2018

Keywords

  • cornea
  • eye
  • lens
  • limbal
  • ocular
  • ophthalmology
  • optic nerve
  • photoreceptors
  • regenerative medicine
  • retina
  • retinal ganglion cells
  • retinal pigment epithelium
  • stem cells
  • trabecular meshwork

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