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Regional cerebral blood flow and FDG uptake in asymptomatic HIV-1 men

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Karen J. Towgood, Mervi Pitkanen, Ranjababu Kulasegaram, Alex Fradera, Suneeta Soni, Naomi Sibtain, Laurence J. Reed, Caroline Bradbeer, Gareth J. Barker, Joel T. Dunn, Fernando Zelaya, Michael D. Kopelman

Original languageEnglish
Pages (from-to)2484-2493
Number of pages10
JournalHuman Brain Mapping
Issue number10
Early online date12 Apr 2012
Publication statusPublished - Oct 2013

King's Authors


Despite advances in the treatment of patients with human immunodeficiency virus (HIV), HIV-associated neurocognitive disorder occurs in 15-50% of HIV-infected individuals, and may become more apparent as ageing advances. In the present study we investigated regional cerebral blood flow (rCBF) and regional cerebral metabolic rate of glucose uptake (rCMRglc) in medically and psychiatrically stable HIV-1-infected participants in two age-groups. Positron emission tomography (PET) and magnetic resonance imaging (MRI)-based arterial spin labeling (ASL) were used to measure rCMRglc and rCBF, respectively, in 35 HIV-infected participants and 37 HIV-negative matched controls. All participants were currently asymptomatic with undetectable HIV-1 viral loads, without medical or psychiatric comorbidity, alcohol or substance misuse, stable on medication for at least 6 months before enrolment in the study. We found significant age effects on both ASL and PET with reduced rCBF and rCMRglc in related frontal brain regions, and consistent, although small, reductions in rCBF and rCMRglc in the anterior cingulate cortex (ACC) in HIV, a finding of potential clinical significance. There was no significant interaction between HIV status and the ageing process, and no significant HIV-related changes elsewhere in the brain on PET or ASL. This is the first paper to combine evidence from ASL and PET method in HIV participants. These finding provide evidence of crossvalidity between the two techniques, both in ageing and a clinical condition (HIV).

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