Regulating Rho GTPases and their regulators

Richard G. Hodge; Anne J. Ridley

doi:10.1038/nrm.2016.67

Regulating Rho GTPases and their regulators

Richard G. Hodge, Anne J. Ridley^*

^*Corresponding author for this work

Director of MRC Centre in Allergic Mechanisms of Asthma

Research output: Contribution to journal › Article › peer-review

599 Citations (Scopus)

Abstract

Rho GTPases regulate cytoskeletal and cell adhesion dynamics and thereby coordinate a wide range of cellular processes, including cell migration, cell polarity and cell cycle progression. Most Rho GTPases cycle between a GTP-bound active conformation and a GDP-bound inactive conformation to regulate their ability to activate effector proteins and to elicit cellular responses. However, it has become apparent that Rho GTPases are regulated by post-translational modifications and the formation of specific protein complexes, in addition to GTP-GDP cycling. The canonical regulators of Rho GTPases-guanine nucleotide exchange factors, GTPase-activating proteins and guanine nucleotide dissociation inhibitors-are regulated similarly, creating a complex network of interactions to determine the precise spatiotemporal activation of Rho GTPases.

Original language	English
Pages (from-to)	496-510
Number of pages	15
Journal	NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume	17
Issue number	8
DOIs	https://doi.org/10.1038/nrm.2016.67
Publication status	E-pub ahead of print - 15 Jun 2016

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Regulating Rho GTPases and their regulators

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